PMID: 6981162Mar 1, 1982Paper

Single-dose therapy with trimethoprim-sulfamethoxazole for urinary tract infection in women

Reviews of Infectious Diseases
N E Tolkoff-RubinR H Rubin

Abstract

One-hundred-four women with symptoms of lower urinary tract inflammation (dysuria, frequency, and suprapubic tenderness) were randomly assigned to one of two treatment regimens: either a single dose of two double-strength trimethoprim-sulfamethoxazole, (TMP-SMZ) tablets (320 mg of TMP and 1,600 mg of SMZ) or conventional therapy of one double-strength tablet (160 mg of TMP and 800 mg of SMZ) twice a day for 10 days. Eighty-one patients had true bacteriuria; 93% of the infections were eradicated by single-dose therapy and 95% by conventional therapy. Results of an antibody-coated bacteria assay showed no correlation with therapeutic outcome. Clinically important side effects were observed in 4% of patients treated with single-dose therapy and 24% (P less than 0.05) of those treated with conventional therapy. Twenty-three patients had acute urethral syndrome, 14 with and nine without pyuria on initial urinalysis. The 14 with pyuria responded to antimicrobial therapy, whereas those without pyuria did not. This response pattern is consistent with recent data concerning the etiology of acute urethral syndrome. It is concluded that single-dose TMP-SMZ therapy is effective, easily administered, inexpensive, and free from significant s...Continue Reading

Citations

Nov 1, 1987·Journal of American College Health : J of ACH·R Shalom
May 1, 1987·Scandinavian Journal of Primary Health Care·A Baerheim
Jun 1, 1983·European Journal of Clinical Microbiology·J G GuerraE Antunez de Mayolo
Feb 9, 1984·The New England Journal of Medicine·A L Komaroff
Jul 23, 2008·The Cochrane Database of Systematic Reviews·Monika Lutters, Nicole B Vogt-Ferrier
Apr 28, 2004·Journal of General Internal Medicine·Michael B Rothberg, John B Wong
May 1, 1987·Scandinavian Journal of Primary Health Care·J Sander
Jan 1, 1988·Drug Intelligence & Clinical Pharmacy·G G Zhanel, A R Ronald
Dec 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·R RazI Potasman
Jun 1, 1984·Mayo Clinic Proceedings·H J SchultzF T Nobrega
Apr 1, 1985·Antimicrobial Agents and Chemotherapy·J RosenstockW W Karney
May 1, 1984·Antimicrobial Agents and Chemotherapy·N E Tolkoff-RubinR H Rubin

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