Single-dose vs multiple-dose antibiotic prophylaxis in instrumented lumbar fusion--a prospective study

Surgical Neurology
Leslie C HellbuschJohn S Treves

Abstract

This prospective investigation was designed to determine if the postoperative infection rate in instrumented lumbar spinal fusion is affected by postoperative antibiotic use. Two hundred sixty-nine patients were randomized into either a preoperative only protocol or preoperative with an extended postoperative antibiotic protocol. The preoperative only protocol received a single dose of cefazolin IV. The extended postoperative antibiotic protocol received the same preoperative dose plus postoperative cefazolin IV every 8 hours for 3 days followed by oral cephalexin every 6 hours for 7 days. Because of untoward drug reaction or deviation from the antibiotic protocol, 36 of the 269 patients were eliminated from the study. Therefore, 233 patients completed the entire study. There was no significant difference in infection rates between the 2 antibiotic protocols. The postoperative infection rates were 4.3% for the preoperative only protocol and 1.7% for the preoperative with extended antibiotic protocol. The overall postoperative infection rate was 3%. However, 5 variables of blood transfusion, electrophysiologic monitoring, increased height, increased weight, and increased body mass index appeared to demonstrate a trend toward inc...Continue Reading

References

Jul 1, 1988·Journal of Neurosurgery·R DempseyP Tibbs
Jun 1, 1986·Journal of Neurosurgery·H D Mollman, S J Haines
Jan 23, 1998·Journal of Spinal Disorders·L E WeissS R Garfin
Jun 12, 1998·The Australian and New Zealand Journal of Surgery·M McDonaldA Forbes
Dec 16, 1998·Southern Medical Journal·S D HodgesN G Kurzynske
Mar 26, 2003·Journal of Neurosurgery·Margaret A OlsenVictoria J Fraser
Nov 5, 2003·Spine·Matthew A DobzyniakHarry N Herkowitz

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Citations

Dec 18, 2013·Surgical Neurology International·Manish K KasliwalVincent C Traynelis
Jan 10, 2014·Der Anaesthesist·F ReutterM A Punke
May 7, 2010·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·J J P SchimmelJ van Limbeek
May 5, 2010·Neurosurgical Review·Dorothee WachterDieter-Karsten Böker
Jan 10, 2012·International Orthopaedics·Andrew Quaile
Mar 7, 2013·Surgical Infections·Dale W BratzlerUNKNOWN Society for Healthcare Epidemiology of America (SHEA)
Nov 5, 2011·Molecular Human Reproduction·Yee-Ming LeeChii-Ruey Tzeng
Aug 31, 2013·The Spine Journal : Official Journal of the North American Spine Society·William O ShafferUNKNOWN North American Spine Society
Apr 22, 2015·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Erol OksuzUnal Erkorkmaz
Jun 9, 2016·Revista Brasileira De Ortopedia·Charbel Jacob JúniorJosé Lucas Batista Júnior
Nov 7, 2016·The Lancet Infectious Diseases·Benedetta AllegranziUNKNOWN WHO Guidelines Development Group
Mar 8, 2019·The Journal of Bone and Joint Surgery. American Volume·Timothy L TanJavad Parvizi
Feb 28, 2019·Clinical Orthopaedics and Related Research·Sean P RyanUNKNOWN American Association of Hip and Knee Surgeons Research Committee
May 6, 2020·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·David K WarrenUNKNOWN CDC Prevention Epicenter Program
Mar 14, 2016·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Vijay H D KamathKenneth Man Chee Cheung
May 18, 2018·Orthopaedic Surgery·Pablo Andrés-CanoEnrique Guerado
Jan 15, 2021·The Spine Journal : Official Journal of the North American Spine Society·Bertrand DebonoHans D de Boer
Dec 15, 2020·The Journal of Bone and Joint Surgery. American Volume·Matthew V AbolaThemistocles S Protopsaltis

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