Single doses of MK-801, a non-competitive antagonist of NMDA receptors, increase the number of 5-HT1A serotonin receptors in the rat brain

Brain Research
K WedzonyB Michalska

Abstract

In the present study, we investigated the impact of MK-801, a non-competitive NMDA receptor antagonist, on the density of serotonergic receptors of the 5-HT1A subtype and on the metabolism of serotonin in various regions of the rat brain containing terminals and cell bodies of serotonergic neurons. The binding of [3H]8-OH-DPAT to 5-HT1A serotonin receptors was increased after MK-801 (0.4 mg/kg) as was shown by autoradiographic studies in the frontal, cingulate and part of enthorinal cortex, subregions of the hippocampus and raphe nuclei. The above receptor changes were observed at 2 h and, in some brain regions, at 24 h after MK-801. In saturation binding studies, an increase in the Bmax value in the rat hippocampus was found after MK-801 (0.4 mg/kg) while no changes being noted in the Kd value. MK-801 (0.4 mg/kg) increased the concentration of the serotonin metabolite 5-HIAA in the prefrontal cortex and hippocampus, respectively, at 2 and 3 or 3 h after administration, being without effect on the level of serotonin. In the dorsal raphe nucleus, MK-801 (0.4 mg/kg) decreased the level of serotonin without affecting the level 5-HIAA (0.5 h after administration) or increased the level of 5-HIAA without altering the concentration o...Continue Reading

Citations

Apr 21, 2016·Reviews in the Neurosciences·Alberto Rubio-Casillas, Alonso Fernández-Guasti
Apr 29, 1998·Stroke; a Journal of Cerebral Circulation·M A HelfaerR J Traystman
Apr 18, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Anna CzyrakKrzysztof Wedzony
Sep 18, 2001·Current Psychiatry Reports·D C Javitt
Nov 17, 2015·The International Journal of Neuropsychopharmacology·Yoshiteru TakekitaAlessandro Serretti
Apr 21, 2007·Journal of Neural Transmission·E Poleszak

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