Single embryo transfer with comprehensive chromosome screening results in improved ongoing pregnancy rates and decreased miscarriage rates.

Human Reproduction
E J FormanRichard T Scott

Abstract

Single embryo transfer (SET) provides the most certain means to reduce the risk of multiple gestation. Regrettably, prospective trials of SET have demonstrated reductions in per-cycle delivery rates. A validated method of comprehensive chromosome screening (CCS) has the potential to optimize SET by transferring only euploid embryos. This retrospective study evaluates the efficacy of SET with CCS in an infertile population. Overall and age-controlled ongoing pregnancy rates (OPR) were compared between women undergoing SET following CCS (CCS-SET, n= 140) and those undergoing SET without aneuploidy screening (control SET, n= 182). All transfers were at the blastocyst stage, with CCS performed after trophectoderm biopsy of expanded blastocysts and analysis with rapid PCR allowing for fresh transfer. In the CCS-SET and control SET groups, an OPR of 55.0 and 41.8%, respectively, was obtained. The OPR was lower for the control group (P< 0.01) despite a younger age than the CCS group (37.3 ± 3.4 versus 34.2 ± 3.9 years; P< 0.001). Birthweight and gestational age at delivery were equivalent. The proportion of clinical pregnancies resulting in miscarriage was higher in the control group (24.8 versus 10.5%, P< 0.01), with more patients re...Continue Reading

References

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Citations

Mar 31, 2012·Journal of Assisted Reproduction and Genetics·Richard T ScottWilliam B Schoolcraft
Jul 12, 2013·Journal of Assisted Reproduction and Genetics·Jason E Swain
Oct 23, 2013·Reproductive Biomedicine Online·Peter Braude
Mar 8, 2013·Human Reproduction Update·Kristien HensGuido de Wert
Jun 26, 2012·Current Opinion in Obstetrics & Gynecology·Francesco Fiorentino
Jun 22, 2013·Current Opinion in Obstetrics & Gynecology·Yvonne E M Koot, Nick S Macklon
Apr 30, 2014·BioMed Research International·Ermanno GrecoFrancesco Fiorentino
Mar 25, 2014·Journal of Assisted Reproduction and Genetics·Scott MorinSantiago Munné
Mar 4, 2014·Reproductive Biomedicine Online·Alexis AdlerJames Grifo
Jul 6, 2014·Obstetrics and Gynecology International·Ming-Yih WuYu-Shih Yang
Dec 10, 2013·Seminars in Fetal & Neonatal Medicine·Natalia Babkina, John M Graham
Aug 12, 2014·Journal of Assisted Reproduction and Genetics·C N SalvaggioR T Scott
Jan 9, 2013·Systems Biology in Reproductive Medicine·Steven D HorneHenry H Q Heng
Jan 15, 2015·Systems Biology in Reproductive Medicine·Silvia F FernándezEsther Velilla
Feb 11, 2016·Journal of Assisted Reproduction and Genetics·Norbert GleicherDavid H Barad
Feb 5, 2014·Obstetrics and Gynecology Clinics of North America·Paul R Brezina, William G Kearns
Feb 5, 2014·Obstetrics and Gynecology Clinics of North America·Paul R Brezina, William H Kutteh
Sep 3, 2013·Fertility and Sterility·Alan H Handyside
Jan 29, 2013·Reproductive Biomedicine Online·Ronit Machtinger, Catherine Racowsky
Sep 20, 2015·Fertility and Sterility·Elias M DahdouhJuan Antonio García-Velasco
Mar 5, 2016·Fertility and Sterility·William B Schoolcraft
May 9, 2015·BMC Medical Genomics·Muhammad Abu-ElmagdMohammed Al-Qahtani
Apr 4, 2013·Fertility and Sterility·Eric J FormanRichard T Scott
Dec 3, 2014·Fertility and Sterility·Shuoping ZhangGe Lin

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Methods Mentioned

BETA
PCR
biopsy
biopsies
pregnancy test

Clinical Trials Mentioned

NCT01408433

Software Mentioned

CCS
Open Epi
SET

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