Single-exposure optical focusing inside scattering media using binarized time-reversed adapted perturbation

Optica
Cheng MaLihong V Wang

Abstract

Light scattering inhibits high-resolution optical imaging, manipulation and therapy deep inside biological tissue by preventing focusing. To form deep foci, wavefront shaping techniques that break the optical diffusion limit have been developed. For in vivo applications, such focusing must provide high gain, high speed, and a high focal peak-to-background ratio. However, none of the previous techniques meet these requirements simultaneously. Here, we overcome this challenge by rapidly measuring the perturbed optical field within a single camera exposure followed by adaptively time-reversing the phase-binarized perturbation. Consequently, a phase-conjugated wavefront is synthesized within a millisecond, two orders of magnitude shorter than the digitally achieved record. We demonstrated real-time focusing in dynamic scattering media, and extended laser speckle contrast imaging to new depths. The unprecedented combination of fast response, high gain, and high focusing contrast makes this work a major stride toward in vivo deep tissue optical imaging, manipulation, and therapy.

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Citations

Sep 15, 2016·Journal of Biomedical Optics·Ashton S HemphillLihong V Wang
Dec 1, 2017·Biomedical Optics Express·Muhammad Mohsin QureshiEuiheon Chung
Apr 16, 2016·Optics Letters·Jonathan V ThompsonVladislav V Yakovlev
Jun 15, 2019·Optics Letters·Ayumu IshijimaKeiichi Nakagawa
Aug 4, 2021·Light, Science & Applications·Zhongtao Cheng, Lihong V Wang

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