Single injection of platelet-rich plasma as a novel treatment of carpal tunnel syndrome

Neural Regeneration Research
Michael Alexander MalahiasVasileios S Nikolaou

Abstract

Both in vitro and in vivo experiments have confirmed that platelet-rich plasma has therapeutic effects on many neuropathies, but its effects on carpal tunnel syndrome remain poorly understood. We aimed to investigate whether single injection of platelet-rich plasma can improve the clinical symptoms of carpal tunnel syndrome. Fourteen patients presenting with median nerve injury who had suffered from mild carpal tunnel syndrome for over 3 months were included in this study. Under ultrasound guidance, 1-2 mL of platelet-rich plasma was injected into the region around the median nerve at the proximal edge of the carpal tunnel. At 1 month after single injection of platelet-rich plasma, Visual Analogue Scale results showed that pain almost disappeared in eight patients and it was obviously alleviated in three patients. Simultaneously, the disabilities of the arm, shoulder and hand questionnaire showed that upper limb function was obviously improved. In addition, no ultrasonographic manifestation of the carpal tunnel syndrome was found in five patients during ultrasonographic measurement of the width of the median nerve. During 3-month follow-up, the pain was not greatly alleviated in three patients. These findings show very encourag...Continue Reading

References

Mar 11, 2004·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·J R GreensladeD J Warwick
Sep 24, 2008·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Jay SmithJeffrey M Payne
Jul 14, 2009·Rheumatology International·Yeşim Sücüllü KaradağWalter Grassi
Jan 20, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yuichi YoshiiPeter C Amadio
Dec 2, 2011·Hand : Official Journal of the American Association for Hand Surgery·Mathew S PrimeNicholas J Goddard
Oct 31, 2013·International Journal of Dermatology·Sukma AnjayaniMuh Dali Amiruddin
Jan 17, 2015·Frontiers in Surgery·Michael-Alexander MalahiasVasileios S Nikolaou

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Citations

Nov 16, 2016·Expert Opinion on Biological Therapy·Mikel SánchezSabino Padilla
Apr 8, 2017·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Eduardo AnituaMohammad H Alkhraisat
Feb 1, 2018·Journal of Clinical Medicine·Unai García de CortázarMikel Sánchez
Nov 28, 2017·Journal of Experimental Orthopaedics·Christopher CentenoMichael Freeman
Jul 20, 2018·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Michael-Alexander MalahiasGeorge C Babis
Feb 13, 2018·BMC Musculoskeletal Disorders·Seyed Ahmad RaeissadatLeila Bagherzadeh
Feb 2, 2019·Journal of Tissue Engineering and Regenerative Medicine·Serdar Can GüvenAyşen Akıncı
Nov 28, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Chih-Ya ChangYung-Tsan Wu
Aug 20, 2019·Clinical Rheumatology·Mohammad K SennaAlaa Ali Awad Ali
Mar 3, 2017·Neural Regeneration Research·Mikel SánchezSabino Padilla
Sep 6, 2017·Journal of Tissue Engineering and Regenerative Medicine·Michael-Alexander MalahiasGeorge C Babis
Jun 10, 2021·International Journal of Clinical Practice·Yu-Ping ShenYung-Tsan Wu

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Methods Mentioned

BETA
density gradient centrifugations

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