Single injection of PTH improves osteoclastic parameters of remodeling at a stress fracture site in rats

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Mahmoud M BakrMark R Forwood

Abstract

Stress fractures (SFx) result from repetitive cyclical loading of bone. They are frequent athletic injuries and underlie atypical femoral fractures following long-term bisphosphonate (BP) therapy. We investigated the effect of a single PTH injection on the healing of SFx in the rat ulna. SFx was induced in 120 female Wistar rats (300 ± 15 g) during a single loading session. A single PTH (8 µg.100g-1 ) or vehicle (VEH) saline injection was administered 24 h after loading. Rats were divided into four groups (n = 15) and ulnae were examined 1, 2, 6, or 10 weeks following SFx. Two Toluidine Blue and TRAP-stained sections of the SFx were examined for histomorphometric analysis using Osteomeasure™ software. An increase in osteoclast number (N.Oc) and perimeter (Oc.Pm) was observed two weeks following PTH treatment (p < 0.01). At 6 weeks, bone formation was the main activity in BMUs. At 10 weeks, the proportion of healing along the SFx line remained 50% greater in PTH groups (p = 0.839), leading to a 43% reduction in the porosity area of BMU (p = 0.703). The main effect of time was a significant variable along the entire SFx remodeling cycle, with significant interactions between time and treatment type affecting (N.Oc) (p = 0.047) an...Continue Reading

References

Jun 3, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T T AndreassenH Oxlund
Aug 17, 1999·The Journal of Clinical Investigation·R L JilkaS C Manolagas
Jan 11, 2000·Clinical Orthopaedics and Related Research·G HolzerT A Einhorn
Nov 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Arata NakajimaMasashi Yamazaki
Mar 24, 2004·Trends in Endocrinology and Metabolism : TEM·Ling QinNicola C Partridge
Apr 22, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·C SeebachP Aspenberg
Feb 11, 2005·The American Journal of Sports Medicine·Martti J KiuruHarri K Pihlajamäki
Jun 9, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Gerald FriedlHarald Dobnig
Aug 8, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sanjeev KakarGeorge L Barnes
Jul 15, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Per AspenbergMark C Lakshmanan
Dec 7, 2010·Clinical Orthopaedics and Related Research·Tarek SibaiThomas A Einhorn
May 21, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·L J KiddM R Forwood
Sep 3, 2013·Journal of Cellular Biochemistry·Nigel A MorrisonGeoff C Nicholson
Mar 13, 2014·Current Osteoporosis Reports·Per Aspenberg, Jörg Schilcher

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Citations

Dec 17, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Chenggui ZhangChunli Song

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