Single injection recombinant vesicular stomatitis virus vaccines protect ferrets against lethal Nipah virus disease

Virology Journal
Chad E MireThomas W Geisbert

Abstract

Nipah virus (NiV) is a highly pathogenic zoonotic agent in the family Paramyxoviridae that is maintained in nature by bats. Outbreaks have occurred in Malaysia, Singapore, India, and Bangladesh and have been associated with 40 to 75% case fatality rates. There are currently no vaccines or postexposure treatments licensed for combating human NiV infection. Four groups of ferrets received a single vaccination with different recombinant vesicular stomatitis virus vectors expressing: Group 1, control with no glycoprotein; Group 2, the NiV fusion protein (F); Group 3, the NiV attachment protein (G); and Group 4, a combination of the NiV F and G proteins. Animals were challenged intranasally with NiV 28 days after vaccination. Control ferrets in Group 1 showed characteristic clinical signs of NiV disease including respiratory distress, neurological disorders, viral load in blood and tissues, and gross lesions and antigen in target tissues; all animals in this group succumbed to infection by day 8. Importantly, all specifically vaccinated ferrets in Groups 2-4 showed no evidence of clinical illness and survived challenged. All animals in these groups developed anti-NiV F and/or G IgG and neutralizing antibody titers. While NiV RNA was...Continue Reading

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Citations

Mar 15, 2016·Vaccine·Benjamin A SatterfieldGregg N Milligan
Jul 15, 2015·Interdisciplinary Sciences, Computational Life Sciences·Mohammad Tuhin AliFaizule Hassan
Aug 16, 2015·Brain Pathology·Kien Chai Ong, Kum Thong Wong
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May 6, 2016·Journal of Virology·Benjamin A SatterfieldChad E Mire
Jun 25, 2015·Nature Communications·Benjamin A SatterfieldChad E Mire
Jun 27, 2014·Science Translational Medicine·Thomas W GeisbertChristopher C Broder
Sep 30, 2020·Annual Review of Virology·Moushimi Amaya, Christopher C Broder
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Jul 2, 2019·Current Pharmaceutical Design·Pritika RamharackMahmoud E S Soliman

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Methods Mentioned

BETA
fluorescence microscopy
PCR
chips

Software Mentioned

VetScan
CFX Manager
Plex Manager
Bio

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