PMID: 8610639Apr 1, 1996Paper

Single institution experience with recombinant gamma-interferon in the treatment of patients with metastatic renal cell carcinoma

American Journal of Clinical Oncology
S Mani, W J Poo

Abstract

We report the clinical course of eight patients with metastatic renal cell carcinoma (RCC) who were treated with recombinant gamma-interferon (Immuneron) as part of a phase II-III study comparing the safety and efficacy of gamma-interferon with that of medroxyprogesterone acetate (Depo-Provera). There were no objective responders among the eight patients treated with recombinant gamma-interferon at an i.v. dose of 1 mg/m(2) daily for five days every other week for four weeks then 1 mg/m(2) three times a week given every other week until there was documented disease progression or complete response (CR). Overall median survival was 17.3 months (range 1.4 to 184). The major side effects of treatment included fever/chills (75%), mild anorexia and fatigue (75%), nausea/vomiting (80%), leukopenia (38%), and abnormal liver function tests (25%). There were no life-threatening side effects observed. At our institution, in a random cohort of eight patients with metastatic RCC, recombinant gamma-interferon when given at a dose of 1 mg/m(2) per day given three times per week on an every other week schedule yields no clinical antitumor activity. A review of the literature on the use of gamma-interferon for metastatic RCC suggests that low-...Continue Reading

References

Dec 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W AulitzkyC Huber
Jan 1, 1989·Seminars in Surgical Oncology·T J Dougherty
Feb 1, 1988·The Journal of Urology·M B GarnickS A Rudnick
Jan 1, 1988·Seminars in Surgical Oncology·A D GeboersO Damsma
Jan 1, 1981·Cancer·A B MillerA Winkler
Sep 1, 1994·The Journal of Urology·J A EllerhorstC J Logothetis
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B EscudierT Hercend

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Citations

Aug 30, 2003·Current Pain and Headache Reports·Jonathan R Kerr, David A J Tyrrell
Feb 14, 2006·Seminars in Oncology·Justin FloydMichael C Perry
Dec 5, 2012·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Mitsuru AndoYoshinobu Takakura
Jul 14, 1998·American Journal of Hematology·R V Gardner
Oct 9, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Trevor E AngellAlan L Epstein
Jan 10, 2002·Journal of Pharmaceutical Sciences·Husam M Younes, Brian G Amsden

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