Single intra-articular injection of lightly cross-linked hyaluronic acid reduces knee pain in symptomatic knee osteoarthritis: a multicenter, double-blind, randomized, placebo-controlled trial

Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA
Stephanie C Petterson, Kevin D Plancher

Abstract

The primary objective was to demonstrate the safety and effectiveness of Monovisc™ in the relief of joint pain in patients with idiopathic knee OA compared to saline injection. It was hypothesized that patient success, defined as ≥ 50% improvement from baseline and ≥ 20 mm absolute improvement from baseline in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) visual analog scale (VAS) pain score, would be greater in the Monovisc™ group compared to the Saline control group. In this multicenter, double-blind, randomized, placebo-controlled trial, patients with idiopathic, symptomatic, knee OA were randomized to either 4 ml single injection of Monovisc™ or 4 ml injection of 0.9% saline. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) was used to assess patient outcomes at 2, 4, 8, 12, 20, and 26 weeks post-injection. The primary effectiveness endpoint was a 50% improvement and ≥ 20 mm improvement from baseline in the WOMAC pain through 26 weeks. Secondary outcome measures included a ≥ 20 mm improvement from baseline on the WOMAC physical function, patient global assessment, evaluator global assessment, and knee range of motion. 369 patients (154 male, 215 female) were randomized ...Continue Reading

References

Apr 17, 2001·Clinical Orthopaedics and Related Research·K D BrandtP T Lavin
Dec 1, 1957·Annals of the Rheumatic Diseases·J H KELLGREN, J S LAWRENCE
Mar 17, 2004·Clinical Orthopaedics and Related Research·Victor M Goldberg, Richard D Coutts
Jun 18, 2004·Current Medical Research and Opinion·Gabriel FríasEduardo Collantes
Oct 20, 2006·Population Health Metrics·Catherine M MichaudChristopher J L Murray
Sep 2, 2008·Arthritis and Rheumatism·Louise MurphyJoanne M Jordan
Jan 25, 2013·The Journal of Bone and Joint Surgery. American Volume·Alexander M WeinsteinElena Losina
Apr 19, 2013·Annals of the Rheumatic Diseases·Linda FernandesUNKNOWN European League Against Rheumatism (EULAR)
Nov 13, 2013·Seminars in Arthritis and Rheumatism·Raveendhara R BannuruTimothy E McAlindon
Jan 5, 2014·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Raveendhara R BannuruLouis F McIntyre
Jan 28, 2014·Osteoarthritis and Cartilage·T E McAlindonM Underwood
May 23, 2015·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Kirk A CampbellNikhil N Verma
Sep 4, 2015·The Journal of Bone and Joint Surgery. American Volume·Hilal Maradit KremersDaniel J Berry
Nov 19, 2015·The American Journal of Sports Medicine·Roy D AltmanEmil Schemitsch
Dec 29, 2017·The Journal of the American Academy of Orthopaedic Surgeons·Victor Rex CarlsonZachary Douglas Post
Jun 1, 2018·Open Access Rheumatology : Research and Reviews·Ross LeightonThierry Conrozier

❮ Previous
Next ❯

Citations

Jul 17, 2019·Arthritis Research & Therapy·ZeYu HuangVirginia Byers Kraus
Mar 14, 2021·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Di ZhaoJun Liu
Apr 28, 2021·Journal of Evidence-based Integrative Medicine·Dai SugimotoGianmichel D Corrado

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.