PMID: 9169860May 15, 1997Paper

Single K channel currents in Schwann cells from normal and neurofibromatosis-affected damselfish

Journal of Neuroscience Research
L A Fieber

Abstract

Damselfish neurofibromatosis is a naturally occurring disease of a tropical marine fish species. Affected fish exhibit peripheral nerve sheath tumors which contain morphologically abnormal Schwann cells (SC), similar to tumors encountered in the human disease neurofibromatosis type 1. Unitary A-type K channels in cell-attached membrane patches of SC were studied. Three different K channel conductances of approximately 5, 10, and 15 pS were present in both normal SC (n = 10) and tumored SC (n = 9). The variability in K channel conductance coincided with a large range of both mean open time and open probability in patches from normal and tumored SC. Channel open time histograms were fit by a single exponential. The ranges of time constants for open times irrespective of conductance were 0.26-9.3 msec in patches from normal cells and 0.60-0.73 msec in patches from tumored cells. These ranges were not significantly different. Inactivation time constants from ensemble averages of single channel currents averaged 83 +/- 46 msec for normal SC and 44 +/- 26 msec for tumored SC, which were not significantly different. These results suggest that A-type K currents from fish SC are composed of channels exhibiting multiple conductances and ...Continue Reading

Citations

Nov 5, 2003·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Lynne A Fieber

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