Single molecule detection from a large-scale SERS-active Au₇₉Ag₂₁ substrate.

Scientific Reports
Hongwen LiuMingwei Chen

Abstract

Detecting and identifying single molecules are the ultimate goal of analytic sensitivity. Single molecule detection by surface-enhanced Raman scattering (SM-SERS) depends predominantly on SERS-active metal substrates that are usually colloidal silver fractal clusters. However, the high chemical reactivity of silver and the low reproducibility of its complicated synthesis with fractal clusters have been serious obstacles to practical applications of SERS, particularly for probing single biomolecules in extensive physiological environments. Here we report a large-scale, free standing and chemically stable SERS substrate for both resonant and nonresonant single molecule detection. Our robust substrate is made from wrinkled nanoporous Au₇₉Ag₂₁ films that contain a high number of electromagnetic "hot spots" with a local SERS enhancement larger than 10⁹. This biocompatible gold-based SERS substrate with superior reproducibility, excellent chemical stability and facile synthesis promises to be an ideal candidate for a wide range of applications in life science and environment protection.

References

Mar 22, 2001·Nature·J ErlebacherK Sieradzki
Feb 9, 2005·Physical Review Letters·P J SchuckW E Moerner
Nov 9, 2006·Journal of the American Chemical Society·Katrin F DomkeBruno Pettinger
Apr 30, 2008·Chemical Society Reviews·Nicholas P W Pieczonka, Ricardo F Aroca
Mar 19, 2009·Journal of the American Chemical Society·Laura Rodríguez-LorenzoF Javier García de Abajo
Dec 17, 2009·Nature Materials·Dong-Kwon LimYung Doug Suh
Mar 20, 2010·Nature·Jian Feng LiZhong Qun Tian
Feb 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Svetlana V Boriskina, Björn M Reinhard
Feb 26, 2011·Journal of the American Chemical Society·Samuel L KleinmanRichard P Van Duyne

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Citations

Jan 3, 2014·Advances in Virology·Swapnil Subhash BawageShree Ram Singh
Jan 16, 2016·Sensors and Actuators. B, Chemical·Samuel S R DasaryAnant K Singh
Sep 25, 2015·ACS Applied Materials & Interfaces·Gobind DasEnzo Di Fabrizio
Sep 9, 2016·ACS Nano·Christine M GabardoLeyla Soleymani
Sep 13, 2013·Scientific Reports·Carlos Díaz ValenzuelaColm O'Dwyer
Jun 27, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Ali O AltunHyung Gyu Park
Dec 18, 2014·Physical Chemistry Chemical Physics : PCCP·Pushkar SinghVolker Deckert
Sep 13, 2017·Chemical Communications : Chem Comm·Dennis G H Hetterscheid
Nov 20, 2012·Nature Materials·Michael P CecchiniJoshua B Edel
Apr 28, 2018·Protein Science : a Publication of the Protein Society·Xinke YuYa-Hong Xie
Aug 8, 2013·Advanced Materials·Pu WangYa-Hong Xie
Jan 24, 2014·Advanced Materials·Manohar ChirumamillaEnzo Di Fabrizio
Oct 24, 2017·Science and Technology of Advanced Materials·Takeshi Fujita
Nov 11, 2014·Optical Materials Express·Himanshu SharmaMichelle Khine
Jun 3, 2014·Nanoscale·Gangaiah MettelaGiridhar U Kulkarni
Apr 24, 2014·The Analyst·Donghyuk KimChristy L Haynes
Oct 4, 2014·Physical Chemistry Chemical Physics : PCCP·Brendan L DarbyEric C Le Ru

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Methods Mentioned

BETA
scanning electron microscopy
Raman scattering

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