Single molecule sensing of amyloid-β aggregation by confined glass nanopores

Chemical Science
Ru-Jia YuYitao Long

Abstract

We have developed a glass nanopore based single molecule tool to investigate the dynamic oligomerization and aggregation process of Aβ1-42 peptides. The intrinsic differences in the molecular size and surface charge of amyloid aggregated states could be distinguished through single molecule induced characteristic current fluctuation. More importantly, our results reveal that the neurotoxic Aβ1-42 oligomer tends to adsorb onto the solid surface of nanopores, which may explain its instability and highly neurotoxic features.

References

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Citations

Jul 7, 2020·Chemical Society Reviews·Kayoung KimChan Beum Park
Jul 28, 2020·The Journal of Chemical Physics·Sebastian SensaleHsueh-Chia Chang
Nov 6, 2020·Quarterly Reviews of Biophysics·Jinming WuJinghui Luo
Mar 29, 2020·ACS Sensors·Nicoletta GiamblancoSebastien Balme
Mar 17, 2021·The Journal of Chemical Physics·Nicolas ArroyoFabien Picaud
May 1, 2021·Sensors and Actuators. B, Chemical·Brian LenhartChang Liu
May 9, 2021·Scientific Reports·Swarnadeep Seth, Aniket Bhattacharya
Dec 3, 2019·Chemical Science·Xiaoyi WangJoshua B Edel
Jun 25, 2021·Chemical Science·Smrithi Krishnan RKozhinjampara R Mahendran
Mar 18, 2020·Analytical Chemistry·Si-Min LuYi-Tao Long
Aug 28, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Silan BaiLishi Wang
Oct 29, 2020·ACS Sensors·Mukhil RaveendranPaolo Actis

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Methods Mentioned

BETA
nuclear
transmission
atomic force microscopy
electrophoresis
chemical modification

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