Oct 8, 2015

Single molecule sequencing of THCA synthase reveals copy number variation in modern drug-type Cannabis sativa L.

BioRxiv : the Preprint Server for Biology
Kevin J McKernanDouglas Smith

Abstract

Cannabinoid expression is an important genetically determined feature of cannabis that presents clinical and legal implications for patients seeking cannabinoid specific therapies like Cannabidiol (CBD). Cannabinoid, terpenoid, and flavonoid marker assisted selection can accelerate breeding efforts by offering genetic tools to select for desired traits at an early stage in growth. To this end, multiple models for chemotype inheritance have been described suggesting a complex picture for chemical phenotype determination. Here we explore the potential role of copy number variation of THCA Synthase using phased single molecule sequencing and demonstrate that copy number and sequence variation of this gene is common and suggests a more nuanced view of chemotype prediction.

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Mentioned in this Paper

Cannabinoids
Terpenes
Genes
Delta(1)-tetrahydrocannabinolic acid synthase
Determination Aspects
3-hydroxyflavone
Genetic Inheritance
Cannabinoid [EPC]
Sequencing
Flavonoids

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