Single-monthly-dose vitamin D supplementation in elderly patients.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
J W GoldzieherV D Castracane

Abstract

To determine the serum levels of calcidiol and calcitriol in 2 men and in 21 postmenopausal, primarily elderly women receiving hormone replacement therapy, orally administered calcium citrate, and an additional supplement of 50,000 IU of vitamin D (1.25 mg of cholecalciferol) once monthly for various periods. We determined plasma calcidiol and calcitriol levels at various times, ranging from -1 to +60 days after intake of a single dose of 1.25 mg of vitamin D in 10 initial or short-term users (1 to 6 months) and in 13 women who had been using this monthly regimen for several years. The primary concerns were the safety and adequacy of the blood levels achieved with a regimen that encouraged compliance. In long-term users of monthly vitamin D regimens, calcidiol levels were usually slightly in excess of the upper limit of normal (that is, >52 ng/mL [>130 nmol/L]) at all times throughout the month; in contrast, calcitriol levels exceeded the normal range (8 to 52 pg/mL [19 to 125 pmol/L]) only once in 18 samplings. In short-term users, calcidiol levels exceeded the normal range only once shortly after intake, and no calcitriol level exceeded the normal range. Once-a-month dosage of 50,000 IU (1.25 mg) of vitamin D in elderly women...Continue Reading

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