Single nanoparticles as versatile phototheranostics for tri-modal imaging-guided photothermal therapy

Biomaterials Science
Xiaomei LuWei Huang

Abstract

Development of versatile phototheranostics is highly desirable for cancer theranostics. Herein, a novel organic conjugated polymer (named DPP-TT) with excellent optical properties was designed and prepared. Based on single-component DPP-TT, single DPP-TT NPs as versatile phototheranostics were developed by a simple nanoprecipitation method. The obtained NPs exhibited good water solubility, excellent biocompatibility, outstanding photostability, strong NIR-I light absorption, and appropriate NIR-II fluorescence emission. Importantly, such NPs presented high photothermal conversion efficiency. From the investigations performed in vitro and in vivo, it was observed that DPP-TT NPs show remarkable performance for cancer theranostics, benefiting from single 808 nm laser-induced tri-modal (NIR-II fluorescence/photoacoustic/thermal) imaging-guided photothermal therapy.

References

Jul 23, 2013·Nature Communications·D J NaczynskiP V Moghe
May 23, 2015·Chemical Reviews·Guosong HongHongjie Dai
Sep 9, 2016·Small·Guangxue Feng, Bin Liu
Aug 24, 2017·Advanced Materials·Yu YangZhuang Liu
Oct 17, 2017·Nature Biotechnology·Qingqing MiaoKanyi Pu
Apr 7, 2018·Advanced Functional Materials·Kangquan ShouZhen Cheng
Aug 4, 2018·Accounts of Chemical Research·Yuyan Jiang, Kanyi Pu
Mar 14, 2019·Journal of the American Chemical Society·Shunjie LiuBen Zhong Tang
Apr 27, 2019·Advanced Materials·Shoujun ZhuHongjie Dai

❮ Previous
Next ❯

Citations

Mar 19, 2021·Current Opinion in Chemical Biology·Aurora BernalCarlos Pérez-Medina
Jul 8, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Guorong ZhangWei Han

❮ Previous
Next ❯

Methods Mentioned

BETA
fluorescence imaging
imaging technique
nanoprecipitation
irradiating

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.