Single near-infrared fluorescent probe with high- and low-sensitivity sites for sensing different concentration ranges of biological thiols with distinct modes of fluorescence signals

Chemical Science
Hua ChenWeiying Lin

Abstract

We describe a unique approach for the development of an interesting type of the fluorescent probes, which can show different modes of fluorescence signals to distinct concentration ranges of a target of interest. The key points for the design of the new type of the fluorescent probes include the judicious selection of the dye platforms and the corresponding high- and low-sensitivity sites. It is known that the normal concentrations of biological thiols have significant biological functions. However, up- or down-regulated concentrations of thiols may induce several diseases. Therefore, it is highly important to monitor the changes of thiol concentrations in living systems. Based on the proposed strategy, we engineer the novel NIR fluorescent probe, CHMC-thiol, which remarkably can display a turn-on signal to the low concentration range of thiols and a ratiometric response to the high concentration range of thiols for the first time. We anticipate that the intriguing strategy formulated herein will be widely useful for the development of concentration range-dependent fluorescent probes.

References

Jan 15, 2004·Journal of the American Chemical Society·Oleksandr RusinRobert M Strongin
Aug 4, 2005·Journal of the American Chemical Society·Hirokazu KomatsuKoji Suzuki
Mar 24, 2007·Journal of the American Chemical Society·Young-Hoon AhnYoung-Tae Chang
Aug 4, 2007·Journal of the American Chemical Society·Meng ZhangChunhui Huang
Oct 2, 2007·Angewandte Chemie·Wei JiangWei Wang
Jun 3, 2009·Journal of the American Chemical Society·Ruslan GuliyevEngin U Akkaya
Aug 21, 2009·Journal of the American Chemical Society·Himali S Hewage, Eric V Anslyn
May 27, 2010·Chemical Society Reviews·Xiaoqiang ChenJuyoung Yoon
Nov 26, 2010·Journal of the American Chemical Society·Yuichiro UenoKevin Burgess
Feb 4, 2011·Angewandte Chemie·Georg M FischerAndreas Zumbusch
Jul 2, 2011·Journal of the American Chemical Society·Chang Su LimBong Rae Cho
Sep 29, 2011·Angewandte Chemie·Mei-Jin LinFrank Würthner
Dec 14, 2011·Journal of the American Chemical Society·Lin YuanSasa Zhu
Jan 27, 2012·Angewandte Chemie·Weimin XuanWei Wang
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Tasuku HirayamaChristopher J Chang
Mar 17, 2012·Angewandte Chemie·Michael Schäferling
Jun 19, 2012·Chemical Reviews·Yuming YangFuyou Li
Jul 24, 2012·Journal of the American Chemical Society·Lin YuanSasa Zhu
Dec 1, 2012·Journal of the American Chemical Society·Naama Karton-LifshinDoron Shabat
Jan 16, 2013·Journal of the American Chemical Society·Yan-Jun HuangYun-Bao Jiang
May 22, 2013·Chemical Society Reviews·Hyo Sung JungJuyoung Yoon
May 25, 2013·Chemical Society Reviews·Caixia YinSidian Li
Dec 24, 2013·Journal of the American Chemical Society·Jing LiuWei Guo
Feb 22, 2014·Journal of the American Chemical Society·Mengchao CuiHideo Saji
Feb 26, 2014·Journal of the American Chemical Society·Alexandra T WrobelPablo Rivera-Fuentes
Mar 4, 2014·ACS Chemical Biology·Luke D Lavis, Ronald T Raines
Apr 12, 2014·Organic Letters·Elodie HeyerRaymond Ziessel
May 9, 2014·Journal of the American Chemical Society·Chunrong LiuMing Xian
Mar 10, 2015·Journal of the American Chemical Society·Jue LingA Prasanna de Silva
May 15, 2015·Chemical Communications : Chem Comm·Xinghui GaoHuimin Ma

❮ Previous
Next ❯

Citations

Apr 9, 2016·Journal of Fluorescence·Qian LiWeiying Lin
Jun 18, 2019·Chemical Society Reviews·Yongkang YueCaixia Yin
Nov 7, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiuli ZhongJian Shen
May 31, 2017·Chemistry, an Asian Journal·Ying LiPengfei Wang
Feb 28, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Longbin XuXinghua Wang
Sep 27, 2018·Luminescence : the Journal of Biological and Chemical Luminescence·Chao WangWeiying Lin
Nov 7, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xuan ZhangMeng-Lu Yang
Jul 14, 2017·Angewandte Chemie·Cai-Xia YinRobert M Strongin
Feb 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yue WangMing-Yu Wu
Dec 29, 2020·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Guo-Jiang MaoGuisheng Zhang
Jun 8, 2021·Chemical Science·Sandip ChakrabortyAyyappanpillai Ajayaghosh
Jun 25, 2021·Chemical Science·Xue TianTony D James
Aug 25, 2016·Analytical Chemistry·Liqiang WangYou-Nian Liu
Dec 21, 2016·Organic Letters·Yongkang YueCaixia Yin
Dec 29, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Changchun WenHong Liang
Feb 9, 2017·Journal of the American Chemical Society·Yongkang YueCaixia Yin

❮ Previous
Next ❯

Methods Mentioned

BETA
Fluorescence
NMR
fluorescence imaging

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.