PMID: 9182800May 1, 1997Paper

Single neuron activity in human hippocampus and amygdala during recognition of faces and objects

Neuron
I FriedC L Wilson

Abstract

The hippocampus and its associated structures play a key role in human memory, yet the underlying neuronal mechanisms remain unknown. Here, we report that during encoding and recognition, single neurons in the medial temporal lobe discriminated faces from inanimate objects. Some units responded selectively to specific emotional expressions or to conjunctions of facial expression and gender. Such units were especially prevalent during recognition, and the responses depended on stimulus novelty or familiarity. Traces of exposure to faces or objects were found a few seconds after stimulus removal as well as 10 hr later. Some neurons maintained a record of previous stimulus presentation that was more accurate than the person's conscious recollection. We propose that the human medial temporal lobe constructs a "cognitive map" of stimulus attributes comparable to the map of the spatial environment described in the rodent hippocampus.

References

Jan 1, 1979·Progress in Neurobiology·J O'Keefe
Jan 29, 1992·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·E T Rolls
Jan 29, 1992·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D I PerrettP J Benson
Feb 1, 1992·Brain : a Journal of Neurology·J G OjemannE Lettich
Feb 1, 1992·Brain : a Journal of Neurology·J SergentB MacDonald
May 29, 1992·Science·M P Young, S Yamane
Jan 2, 1991·Neuroscience Letters·T OnoR Tamura
Jan 1, 1990·Annual Review of Neuroscience·A R DamasioH Damasio
Jan 19, 1990·Science·E Tulving, D L Schacter
Oct 15, 1987·The Journal of Comparative Neurology·R InsaustiW M Cowan
Feb 1, 1989·Journal of Neurophysiology·S FunahashiP S Goldman-Rakic
Dec 3, 1986·Brain Research·C G WibleD S Olton
Jan 28, 1985·Brain Research·T Watanabe, H Niki
Apr 1, 1985·Behavioural Brain Research·C M LeonardG C Baylis
Jul 1, 1971·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D Marr
Jan 1, 1972·Journal of Neurophysiology·C G GrossD B Bender
Mar 31, 1972·Science·G W Van HoesenN Butters
May 1, 1971·Journal of Neurophysiology·K Kubota, H Niki
Aug 13, 1971·Science·J M Fuster, G E Alexander
Sep 1, 1995·Journal of Neurophysiology·A PuceG McCarthy
Dec 1, 1994·Hippocampus·R C O'Reilly, J L McClelland
Jun 1, 1994·Hippocampus·A Treves, E T Rolls
Jun 1, 1994·Journal of Neurophysiology·P M GochinC G Gross
Nov 17, 1994·Nature·A C NobreG McCarthy
Apr 1, 1994·Current Opinion in Neurobiology·M Mishkin, E A Murray
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·P Alvarez, L R Squire
Feb 1, 1994·Journal of Neurophysiology·T AllisonD D Spencer

❮ Previous
Next ❯

Citations

Jan 1, 1997·Hippocampus·S P WiebeJ Ambros-Ingerson
Apr 18, 2003·Hippocampus·Craig E L Stark, Larry R Squire
Jan 29, 2002·Hippocampus·B A Strange, R J Dolan
Aug 23, 2005·Hippocampus·Arne D EkstromMichael J Kahana
Mar 22, 2006·Virchows Archiv : an International Journal of Pathology·Gianni Bussolati
Sep 24, 2005·Anatomy and Embryology·A GorjiE-J Speckmann
Jul 4, 2009·Neuropsychology Review·Michael S KrausRanga K R Krishnan
Oct 21, 2003·Current Neurology and Neuroscience Reports·Steven Z Rapcsak
Feb 13, 2001·Cognition·N Kanwisher
Apr 28, 2001·Journal of Neuroscience Methods·N LudvigJ G Kral
Nov 24, 2001·Behavioural Brain Research·H Eichenbaum
Jun 10, 1998·Progress in Neurobiology·M W Brown, J Z Xiang
Oct 7, 1998·Epilepsy Research·J Engel
Sep 30, 1998·Current Opinion in Neurobiology·N Logothetis
Jun 23, 1998·Current Opinion in Neurobiology·A M Treisman, N G Kanwisher
Nov 24, 1999·Trends in Cognitive Sciences·R Adolphs
Aug 11, 2004·Behavioral Neuroscience·Robert S Astur, R Todd Constable
Oct 29, 2010·Nature·Moran CerfItzhak Fried
Dec 22, 2004·Nature Reviews. Neuroscience·Andreas K EngelGeorge A Ojemann
Mar 11, 2000·The European Journal of Neuroscience·K D BroadK M Kendrick
Dec 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ueli RutishauserAdam N Mamelak
Feb 27, 2008·Proceedings of the National Academy of Sciences of the United States of America·R Quian QuirogaI Fried
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Michael J Jutras, Elizabeth A Buffalo
Mar 17, 2010·Proceedings of the National Academy of Sciences of the United States of America·Rony PazItzhak Fried
Nov 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Uri LivnehRony Paz
Feb 1, 2000·Cognitive Neuropsychology·F TongN Kanwisher
Mar 14, 2007·Cognitive Neuropsychiatry·Bryan A Strange, Raymond J Dolan
Aug 30, 2013·Journal of Clinical and Experimental Neuropsychology·Marco VacanteCeleste A de Jager
Dec 19, 2006·Cerebral Cortex·Daniel YoshorJohn H R Maunsell
Nov 6, 2008·Social Cognitive and Affective Neuroscience·Christiaan van der GaagChristian Keysers
Jan 21, 2012·Social Cognitive and Affective Neuroscience·Jennifer Urbano BlackfordSuzanne N Avery

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.