Single-neuron analysis of human thalamus in patients with intention tremor and other clinical signs of cerebellar disease

Journal of Neurophysiology
F A LenzS G Reich

Abstract

Tremor that occurs as a result of a cerebellar lesion, cerebellar tremor, is characteristically an intention tremor. Thalamic activity may be related to cerebellar tremor because transmission of some cerebellar efferent signals occurs via the thalamus and cortex to the periphery. We have now studied thalamic neuronal activity in a cerebellar relay nucleus (ventral intermediate-Vim) and a pallidal relay nucleus (ventralis oral posterior-Vop) during thalamotomy in patients with intention tremor and other clinical signs of cerebellar disease (tremor patients). The activity of single neurons and the simultaneous electromyographic (EMG) activity of the contralateral upper extremity in tremor patients performing a pointing task were analyzed by spectral cross-correlation analysis. EMG spectra during intention tremor often showed peaks of activity in the tremor-frequency range (1.9-5.8 Hz). There were significant differences in thalamic neuronal activity between tremor patients and controls. Neurons in Vim and Vop had significantly lower firing rates in tremor patients than in patients undergoing thalamic surgery for pain (pain controls). Other studies have shown that inputs to Vim from the cerebellum are transmitted through excitator...Continue Reading

References

Sep 1, 1976·Journal of Neurophysiology·P L Strick
Feb 15, 1979·The Journal of Comparative Neurology·E G JonesJ D Coulter
Sep 1, 1977·Journal of Neurophysiology·T Vilis, J Hore
Jun 1, 1976·Brain : a Journal of Neurology·S GilmanJ Hollenberg
Jan 1, 1992·Movement Disorders : Official Journal of the Movement Disorder Society·H C Diener, J Dichgans
Jan 1, 1989·Brain Research. Brain Research Reviews·T Hirai, E G Jones
Jan 1, 1986·Progress in Brain Research·W T ThachM Horne
Oct 1, 1988·Brain : a Journal of Neurology·N MaiJ Dichgans
Mar 1, 1973·Experimental Neurology·M E Goldberger, J H Growdon
Sep 1, 1967·Brain : a Journal of Neurology·J H GrowdonC N Liu
Aug 1, 1971·Journal of Psychiatric Research·W R Mehler
May 1, 1984·Experimental Neurology·D FlamentJ Hore
May 1, 1995·Movement Disorders : Official Journal of the Movement Disorder Society·F A LenzJ O Dostrovsky
Jan 1, 1994·Movement Disorders : Official Journal of the Movement Disorder Society·M KyllermanG Carlsson
Apr 1, 1997·Journal of Neurophysiology·J G Keating, W T Thach
Nov 25, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·G DeuschlM Brin
Feb 1, 1955·The Journal of Comparative Neurology·R M CARREA, F A METTLER

❮ Previous
Next ❯

Citations

Jun 23, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Timothy L HansonMiguel A L Nicolelis
Jul 5, 2011·Neuroscience·T Wichmann, J O Dostrovsky
Jun 8, 2011·The European Journal of Neuroscience·Masayuki Watanabe, Douglas P Munoz
Jan 1, 2010·Neuromodulation : Journal of the International Neuromodulation Society·Kazutaka KobayashiHideki Atsumi
Dec 31, 2005·Neurosurgery·Clement HamaniAndres M Lozano
Jul 23, 2016·Journal of Neurosurgery·Nicolas Kon Kam KingWilliam D Hutchison
Sep 13, 2005·Stereotactic and Functional Neurosurgery·Yasuhiro ShimojimaShu-ichi Ikeda
Nov 2, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Rodger J Elble, UNKNOWN Tremor Research Group
Jul 17, 2004·Journal of Neurosurgery·Jason A BrodkeyAndres M Lozano
Jun 2, 2015·Neurosurgical Focus·Allen L HoCasey H Halpern
Mar 29, 2005·Neurosurgery·Mary Say PayneBryan Rankin Payne
Feb 15, 2010·Contemporary Neurosurgery·W S AndersonF A Lenz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.