Single nucleotide insertion in the 5'-untranslated region of hepatitis C virus with clearance of the viral RNA in a liver transplant recipient during acute hepatitis B virus superinfection

Liver
Consolato SergiWalter J Hofmann

Abstract

Hepatitis C virus (HCV) infection is an important etiology in patients undergoing orthotopic liver transplantation (OLT) world-wide. Antiviral therapy-related clearance of HCV RNA may occur both in patients with chronic HCV infection and in transplanted patients for HCV-related liver cirrhosis, but the role of the 5'-untranslated region (UTR) of HCV containing the internal ribosome entry site (IRES), which directs the translation of the viral open reading frame has not hitherto been evaluated. We studied the 5'-UTR in an HCV-infected recipient of a liver graft that showed spontaneous clearance of HCV RNA during an acute hepatitis B virus (HBV) superinfection. Sequencing of the 5'-UTR of HCV showed a nucleotide A insertion at position 193 of the IRES.

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Citations

Apr 24, 2010·Journal of Human Genetics·Tae Joon ParkHyoung Doo Shin
Aug 30, 2006·Scandinavian Journal of Infectious Diseases·Wolfgang JessnerWolfgang Vogel
Apr 27, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Teresa Casanovas-TaltavullLuis A Casais
May 15, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Carla S CoffinMark G Swain
Dec 29, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Vishal BhagatArie Regev
Nov 14, 2006·European Journal of Gastroenterology & Hepatology·Lan LinJohan Fevery
Aug 22, 2017·World Journal of Hepatology·Khulood T AhmedVeysel Tahan
Nov 16, 2002·Current Infectious Disease Reports·Sarah L. GeorgeJack T. Stapleton

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