Single-nucleotide Polymorphism of CTLA-4 (rs5742909) in Correlation with Schizophrenia Risk Factor

Journal of Pharmacy & Bioallied Sciences
Riyadi SumirtanurdinMelisa I Barliana

Abstract

Cytotoxic T protein lymphocyte antigen-4 (CTLA-4) plays a key role in regulating the T-cell system, where occurrence of disturbances in the system seen by imbalances in Th1 and Th2 levels is believed to be one of the etiologies of schizophrenia. Single-nucleotide polymorphisms (SNPs) at rs5742909 in the CTLA-4 gene (C→T) might affect the expression level of CTLA-4 protein. The aim of this study was to determine the genotype distribution of the CTLA-4 gene (rs5742909) in patients with schizophrenia at Rumah Sakit Jiwa Prof. Dr. Soerojo Magelang and identify the correlation of these genetic polymorphisms as the risk factors of schizophrenia. This research was conducted through the stage of submitting ethical approval, primer design, chromosomal DNA isolation, optimization of polymerase chain reaction conditions, and data analysis. Based on the results of the study, the CC genotype was shown in 36 patients (78.26%), TT genotype in 10 patients (21.73%), and no TT genotypes. However, statistical analysis using Fisher's exact and binary logistic regression statistical test showed no significant relationship between genetic polymorphism of the CTLA-4 rs5742909 against risk factors for schizophrenia (P = 0.05; α = 5%). SNP at rs5742909...Continue Reading

References

Aug 1, 1995·The Journal of Experimental Medicine·M F Krummel, J P Allison
Aug 1, 1994·Immunity·T L WalunasJ A Bluestone
Dec 15, 1996·Biological Psychiatry·M RothermundtH Kirchner
Oct 28, 1998·Progress in Neuro-psychopharmacology & Biological Psychiatry·C L CazzulloM Clerici
Jan 29, 2000·Kidney International·A R KitchingS R Holdsworth
Mar 26, 2005·Immunological Reviews·Stephen C L GoughDavid M Sansom
Oct 19, 2005·Expert Reviews in Molecular Medicine·Oliver BrandJoanne Heward
Nov 17, 2007·Biological Psychiatry·Stéphane PotvinEdouard Kouassi
May 16, 2008·Epidemiologic Reviews·John McGrathJoy Welham
Jul 11, 2008·Immunological Reviews·Kenneth J Scalapino, David I Daikh
Jul 17, 2008·Schizophrenia Bulletin·Pamela DeRosseAnil K Malhotra
Oct 2, 2008·Perspectives in Psychiatric Care·Debra Rose Wilson, Lita Warise
Oct 14, 2008·Brain, Behavior, and Immunity·Amanda L JonesJudith M Greer
Mar 10, 2009·Schizophrenia Research·Sarah E BergenKenneth S Kendler
Nov 19, 2009·Molecular Psychiatry·J SöderlundG Engberg
May 23, 2015·Neuropsychobiology·Dorota FrydeckaAndrzej Kiejna
Jan 1, 2015·Nature Reviews. Disease Primers·René S KahnThomas R Insel

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BETA
electrophoresis

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