Single Nucleotide Polymorphism (SNP) markers associated with high folate content in wild potato species

PloS One
Sapinder BaliAymeric Goyer

Abstract

Micronutrient deficiency, also known as the hidden hunger, affects over two billion people worldwide. Potato is the third most consumed food crops in the world, and is therefore a fundamental element of food security for millions of people. Increasing the amount of micronutrients in food crop could help alleviate worldwide micronutrient malnutrition. In the present study, we report on the identification of single nucleotide polymorphism (SNP) markers associated with folate, an essential micronutrient in the human diet. A high folate diploid clone Fol 1.6 from the wild potato relative Solanum boliviense (PI 597736) was crossed with a low/medium folate diploid S. tuberosum clone USW4self#3. The resulting F1 progeny was intermated to generate an F2 population, and tubers from 94 F2 individuals were harvested for folate analysis and SNP genotyping using a SolCap 12K Potato SNP array. Folate content in the progeny ranged from 304 to 2,952 ng g-1 dry weight. 6,759 high quality SNPs containing 4,174 (62%) polymorphic and 2,585 (38%) monomorphic SNPs were used to investigate marker-trait association. Association analysis was performed using two different approaches: survey SNP-trait association (SSTA) and SNP-trait association (STA). A...Continue Reading

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Citations

Jun 9, 2020·Critical Reviews in Biotechnology·Ramaswamy ManimekalaiMallikarjuna Kandalam
Sep 18, 2021·Frontiers in Plant Science·C Joe MartinKarl Peter Pauls

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Methods Mentioned

BETA
genotyping

Software Mentioned

JMP Genomics
Genome Studio
GenomeStudio
JMP
SSTA
STA
Illumina GenomeStudio
SAS
KCJr EIA
SolCap

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