Single Nucleotide Polymorphisms in β-Carotene Oxygenase 1 are Associated with Plasma Lycopene Responses to a Tomato-Soy Juice Intervention in Men with Prostate Cancer.

The Journal of Nutrition
Nancy E MoranSteven K Clinton

Abstract

Human plasma and tissue lycopene concentrations are heterogeneous even when consuming controlled amounts of tomato or lycopene. Our objective is to determine whether single nucleotide polymorphisms (SNPs) in or near known or putative carotenoid metabolism genes [β-carotene 15,15' monooxygenase 1 (BCO1), scavenger receptor class B type 1 (SCARB1), ATP-binding cassette transporter subfamily A member 1 (ABCA1), microsomal triglyceride transfer protein (MTTP), apolipoprotein B-48, elongation of very long chain fatty acids protein 2 (ELOVL2), and ATP-binding cassette subfamily B member 1 (ABCB1), and an intergenic superoxide dismutase 2, mitochondrial-associated SNP] are predictive of plasma lycopene responses to steady state tomato juice consumption. Secondary linear regression analyses of data from a dose-escalation study of prostate cancer patients [n = 47; mean ± SEM age: 60 ± 1 y; BMI (in kg/m2): 32 ± 1] consuming 0, 1, or 2 cans of tomato-soy juice/d (163 mL/can; 20.6 mg lycopene 1.2 mg β-carotene/can) for 24 ± 0.7 d before prostatectomy were conducted to explore 11 SNP genotype effects on the change in plasma lycopene and plasma and prostate tissue concentrations of lycopene, β-carotene, phytoene, and phytofluene. Two BCO1 SN...Continue Reading

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Citations

Oct 2, 2020·Current Developments in Nutrition·A Catharine Ross, Nancy E Moran
Mar 3, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·M Luisa BonetAndreu Palou
Feb 9, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Ji Ye Lim, Xiang-Dong Wang
Jun 7, 2020·Archives of Biochemistry and Biophysics·Jelena Mustra Rakic, Xiang-Dong Wang
Mar 26, 2021·Frontiers in Genetics·Manuel CorpasEdmund Lehmann
Sep 23, 2021·The Journal of Nutrition·Yuko YamaguchiRichard D Semba

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