Single Nucleotide Polymorphisms in MIR143 Contribute to Protection Against Non-Hodgkin Lymphoma (NHL) in Caucasian Populations

Genes
Gabrielle BradshawLyn R Griffiths

Abstract

Recent studies show an association of microRNA (miRNA) polymorphisms (miRSNPs) in different cancer types, including non-Hodgkin lymphoma (NHL). The identification of miRSNPs that are associated with NHL susceptibility may provide biomarkers for early diagnosis and prognosis for patients who may not respond well to current treatment options, including the immunochemotherapy drug combination that includes rituximab, cyclophosphamide, doxorubicin, vincristine and prednisome (R-CHOP). We developed a panel of miRSNPs for genotyping while using multiplex PCR and chip-based mass spectrometry analysis in an Australian NHL case-control population (300 cases, 140 controls). Statistical association with NHL susceptibility was performed while using Chi-square (χ²) and logistic regression analysis. We identified three SNPs in MIR143 that are to be significantly associated with reduced risk of NHL: rs3733846 (odds ratio (OR) [95% confidence interval (CI)] = 0.54 [0.33 ⁻ 0.86], p = 0.010), rs41291957 (OR [95% CI] = 0.61 [0.39 ⁻ 0.94], p = 0.024), and rs17723799 (OR [95% CI] = 0.43 [0.26 ⁻ 0.71], p = 0.0009). One SNP, rs17723799, remained significant after correction for multiple testing (p = 0.015). Subsequently, we investigated an associatio...Continue Reading

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Citations

Jun 19, 2019·Genes·Subbaya Subramanian, Clifford J Steer
Apr 22, 2021·PloS One·Marco Antônio Perpétuo de SousaFlavia Lombardi Lopes
May 14, 2021·Nucleosides, Nucleotides & Nucleic Acids·Mahdiyeh Harati-SadeghRamin Saravani

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Methods Mentioned

BETA
PCR
genotyping
Protein Assay
Electrophoresis
chip

Software Mentioned

HaploView
gnomAD
MassARRAY ® Typer
GTEx
Chromas Lite
Image J
SpectroAcquire
Plink
Agena MassARRAY
MassARRAY

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