Single Nucleotide Polymorphisms in the G-Protein Coupled Receptor Kinase 5 (GRK5) Gene are associated with Plasma LDL-Cholesterol Levels in Humans

Scientific Reports
Stefan Z LutzKonstantinos Kantartzis

Abstract

Genetically modified mice models suggest an important role for G-protein-coupled receptor kinase 5 (GRK5) in the pathophysiology of obesity and related disorders. We investigated whether single nucleotide polymorphisms (SNPs) in the gene encoding GRK5 affect cardiometabolic traits in humans. We genotyped 3 common SNPs in intron 1 (rs1980030, rs10466210, rs9325562) and one SNP in intron 3 (rs10886471) of GRK5 in 2332 subjects at risk for type 2 diabetes. Total- and visceral fat mass were measured by magnetic resonance (MR) tomography and liver fat content by 1H-MR spectroscopy. Insulin secretion and sensitivity were estimated during an OGTT and measured during the euglycemic, hyperinsulinemic clamp (n = 498). Carriers of the minor allele of rs10466210 and rs1980030 had higher total- and LDL-cholesterol levels (p = 0.0018 and p = 0.0031, respectively, for rs10466210; p = 0.0035 and p = 0.0081, respectively, for rs1980030), independently of gender, age, BMI and lipid-lowering drugs. The effects of rs10466210 withstood Bonferroni correction. Similar associations were observed with apolipoprotein B levels (p = 0.0034 and p = 0.0122, respectively). Carriers of the minor allele of rs10466210 additionally displayed a trend for higher i...Continue Reading

References

Jun 23, 2005·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·B M BalletshoferH-U Häring
Oct 4, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Konstantinos KantartzisNorbert Stefan
Nov 7, 2006·Biochimica Et Biophysica Acta·Catalina RibasFederico Mayor
Nov 15, 2007·Diabetes Care·Konstantinos KantartzisNorbert Stefan
Aug 13, 2008·Archives of Internal Medicine·Norbert StefanHans-Ulrich Häring
Aug 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey S MartiniWalter J Koch
Nov 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Daniela SorrientoGuido Iaccarino
Feb 4, 2010·The Journal of Biological Chemistry·Xiaoqing ChenLan Ma
Feb 10, 2011·PLoS Genetics·Alexandra C NicaUNKNOWN MuTHER Consortium
Nov 19, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Jiao-Hui WuNeil J Freedman
Apr 18, 2012·Biochemical and Biophysical Research Communications·Feifei WangLan Ma
Nov 1, 2012·Biochemical and Biophysical Research Communications·Li WangLan Ma
Oct 8, 2013·Nature Genetics·Cristen J WillerUNKNOWN Global Lipids Genetics Consortium
Feb 28, 2016·Chinese Journal of Integrative Medicine·Hao-Ying DouHong-Wu Wang
May 18, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jonathan HullmannWalter J Koch
May 18, 2016·The Lancet. Diabetes & Endocrinology·Norbert StefanHans-Ulrich Häring

❮ Previous
Next ❯

Citations

Mar 7, 2021·International Journal of Molecular Sciences·Federica MarzanoAlessandro Cannavo

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping

Software Mentioned

iPLEX
JMP
Sequenom

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Related Papers

The Journal of Clinical Endocrinology and Metabolism
Stefan Z LutzKonstantinos Kantartzis
Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
Axel HauptAndreas Fritsche
Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Konstantinos KantartzisNorbert Stefan
© 2022 Meta ULC. All rights reserved