Single-nucleotide polymorphisms in the KDR gene in pregnancies complicated by gestational hypertensive disorders and small-for-gestational-age infants

Reproductive Sciences
Prabha H AndraweeraClaire T Roberts

Abstract

Pregnancies complicated by preeclampsia and small-for-gestational-age (SGA) infants share placental vascular abnormalities and both disorders confer increased risk of later life coronary artery disease. Kinase insert domain receptor (KDR) is the main receptor for vascular endothelial growth factor A, a potent angiogenic factor which regulates the development of the placental vasculature. Two polymorphisms in KDR (-604T/C and Val297Ile) are known to be associated with coronary artery disease. We investigated the association of these polymorphisms with preeclampsia, gestational hypertension, and SGA infants. Nulliparous pregnant women, their partners, and infants were recruited to a prospective cohort study (n = 1169). Doppler ultrasound of the uterine and umbilical arteries was performed at 20 weeks of gestation. Preeclampsia, gestational hypertension, and SGA were defined according to international guidelines. DNA extracted from peripheral venous or cord blood was genotyped using the Sequenom MassARRAY system. Multivariable logistic regression was used to compare the odds for the pregnancy complications between the genotype groups adjusting for potential confounders. Among 937 Caucasian pregnancies, 427 (45.6%) were uncomplicat...Continue Reading

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Citations

Jun 20, 2015·Molecular Human Reproduction·Prabha H AndraweeraUNKNOWN SCOPE Consortium
Oct 30, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Prabha H AndraweeraClaire T Roberts
Mar 6, 2012·Placenta·P H AndraweeraC T Roberts
Apr 12, 2012·Molecular Human Reproduction·Prabha H AndraweeraUNKNOWN SCOPE Consortium
Feb 20, 2020·Journal of Developmental Origins of Health and Disease·Prabha H AndraweeraClaire T Roberts
May 21, 2014·Journal of Hypertension·Clive J PetryDavid B Dunger
Feb 26, 2015·Pharmacogenetics and Genomics·Immaculate Mbongo LangmiaZahurin Mohamed
Feb 8, 2020·Current Opinion in Toxicology·Katerine S SailiThomas B Knudsen
Jul 25, 2021·Journal of Clinical Medicine·Wiktor WojczakowskiBożena Leszczyńska-Gorzelak
Mar 17, 2019·The Journal of Pediatrics·Prabha H Andraweera, Zohra S Lassi

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Methods Mentioned

BETA
SGA
genotyping

Software Mentioned

PASW
SPSS

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