Single nucleotide polymorphisms in the Trx2/TXNIP and TrxR2 genes of the mitochondrial thioredoxin antioxidant system and the risk of diabetic retinopathy in patients with Type 2 diabetes mellitus

Journal of Diabetes and Its Complications
Sara Mankoc RamusDaniel Petrovič

Abstract

Oxidative stress plays an important role in the pathogenesis of diabetes and its complications. The aim of this study was to examine the possible association between seven single nucleotide polymorphisms (SNPs) of the Trx2/TXNIP and TrxR2 genes encoding proteins involved in the thioredoxin antioxidant defence system and the risk of diabetic retinopthy (DR). Cross-sectional case-control study. A total of 802 Slovenian patients with Type 2 diabetes mellitus; 277 patients with DR and 525 with no DR were enrolled. Patients genotypes of the SNPs; including rs8140110, rs7211, rs7212, rs4755, rs1548357, rs4485648 and rs5748469 were determined by the competitive allele specific PCR method. Each genotype of examined SNPs was regressed in a logistic model, assuming the co-dominant, dominant and the recessive models of inheritance with covariates of duration of diabetes, HbA1c, insulin therapy, total cholesterol and LDL cholesterol levels. In the present study, for the first time we identified an association between the rs4485648 polymorphism of the TrxR2 gene and DR in Caucasians with Type 2 DM. The estimated ORs of adjusted logistic regression models were found to be as follows: 4.4 for CT heterozygotes, 4.3 for TT homozygotes (co-domin...Continue Reading

References

Dec 1, 1992·Diabetes Care·R KleinS E Moss
Jan 1, 1984·Current Eye Research·R E AndersonR D Wiegand
Jan 31, 1997·The Journal of Biological Chemistry·G SpyrouJ Gustafsson
Dec 29, 1998·American Journal of Human Genetics·D M NielsenB S Weir
Mar 31, 1999·Free Radical Research·S LoftH E Poulsen
Apr 24, 1999·European Journal of Biochemistry·A Miranda-VizueteG Spyrou
Dec 10, 1999·Diabetes Research and Clinical Practice·S SuzukiT Toyota
Mar 5, 2003·Journal of Biochemical and Molecular Toxicology·A C MaritimJ B Watkins
Dec 23, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lily L WuJames T Wu
Mar 23, 2004·Biometrics·Wendy Czika, B S Weir
Apr 15, 2004·The Journal of Biological Chemistry·Alexandre PatenaudeMarc-Edouard Mirault
May 7, 2004·The Journal of Biological Chemistry·P Christian SchulzeRichard T Lee
Aug 11, 2004·Molecular Aspects of Medicine·Michael R Duchen
Apr 19, 2005·American Journal of Human Genetics·Jacqueline K Wittke-ThompsonNancy J Cox
Jul 21, 2007·Experimental Diabetes Research·Renu A Kowluru, Pooi-See Chan
Oct 23, 2009·The Journal of Biological Chemistry·Michael T ForresterJonathan S Stamler
Dec 5, 2009·The Journal of Biological Chemistry·Geetu SaxenaAnath Shalev
Jul 14, 2010·Biochimica Et Biophysica Acta·Maria Laura Aon-BertolinoFrancisco Capani
Jul 14, 2010·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·R HaringH Völzke
Oct 12, 2010·The Journal of Biological Chemistry·Eva-Maria HanschmannChristopher Horst Lillig
Jan 14, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·José Butori Lopes de FariaJacqueline Mendonça Lopes de Faria
Jan 21, 2011·European Heart Journal·Dirk SibbingNicolas von Beckerath
Jul 1, 2011·Pharmacogenetics and Genomics·Stella KoutrosLaura E Beane Freeman
Aug 1, 2013·Free Radical Biology & Medicine·Jun Lu, Arne Holmgren
Dec 20, 2013·Journal of Clinical & Experimental Ophthalmology·Lalit P Singh
Dec 21, 2013·Diabetes Care·UNKNOWN American Diabetes Association
Jan 11, 2014·Frontiers in Immunology·Eiji YoshiharaJunji Yodoi
Apr 12, 2014·Annals of Medicine·Seung Joo KangPeter Kruzliak
Jun 25, 2014·Indian Journal of Human Genetics·Monisha Banerjee, Pushpank Vats
Aug 29, 2014·Journal of Ophthalmology·Lorena PerroneLalit P Singh
Dec 3, 2014·Redox Biology·Monisha Banerjee, Pushpank Vats

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.