Single nucleotide polymorphisms in type 2 diabetes among Hispanic adults

Diabetes Research and Clinical Practice
Amanda L WatsonNorman H L Chiu

Abstract

In this pilot study, we explore the genetic variation that may relate to type 2 diabetes (T2D) among Hispanic adults. The genotypes of 36 Hispanic adults were analyzed by using the Cardio-Metabochip. The goal is to identify single nucleotide polymorphisms (SNPs) associated to T2D among Hispanic adults. A total of 26 SNPs were identified to be associated with T2D among Hispanic adults. None of these SNPs have been reported for T2D. By using the principle components analysis to analyze the genotype of 26 SNPs in 36 samples, the samples obtained from diabetic patients could be distinguished from the control samples. The findings support genetic involvement in T2D among Hispanic adults.

References

Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
May 1, 2007·Journal of Diabetes Science and Technology·Bruce W BodeAnnette L Clark
Aug 24, 2010·Trends in Molecular Medicine·Amélie BonnefondMartine Vaxillaire
Dec 2, 2010·Clinical Chemistry·Emma AhlqvistLeif Groop

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