Single Nucleotide Polymorphisms in Vitamin D Receptor Gene Affect Birth Weight and the Risk of Preterm Birth: Results From the "Mamma & Bambino" Cohort and A Meta-Analysis

Nutrients
Martina BarchittaAntonella Agodi

Abstract

The effect of vitamin D receptor gene (VDR) polymorphisms on adverse pregnancy outcomes-including preterm birth (PTB), low birth weight and small for gestational age-is currently under debate. We investigated 187 mother-child pairs from the Italian "Mamma & Bambino" cohort to evaluate the association of maternal VDR polymorphisms-BsmI, ApaI, FokI and TaqI-with neonatal anthropometric measures and the risk of PTB. To corroborate our results, we conducted a meta-analysis of observational studies. For the FokI polymorphism, we showed that gestational duration and birth weight decreased with increasing number of A allele (p = 0.040 and p = 0.010, respectively). Compared to the GG and GA genotypes, mothers who carried the AA genotype exhibited higher PTB risk (OR = 12.049; 95% CI = 2.606⁻55.709; p = 0.001) after adjusting for covariates. The meta-analysis confirmed this association under the recessive model (OR = 3.67, 95%CI 1.18⁻11.43), and also pointed out the protective effect of BsmI polymorphism against the risk of PTB under the allelic (A vs. G: OR = 0.74; 95%CI 0.59⁻0.93) and recessive (AA vs. GG + AG: OR = 0.62; 95%CI 0.43⁻0.89) models. Our results suggest the association between some maternal VDR polymorphisms with neon...Continue Reading

References

Jul 1, 1994·American Journal of Public Health·E LiebermanA P Cohen
Jul 1, 1997·Proceedings of the Society for Experimental Biology and Medicine·S A Strugnell, H F Deluca
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Apr 22, 1999·Archives of Disease in Childhood·C TaoC T Cowell
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Jan 10, 2003·Journal of Cellular Biochemistry·Michael F Holick
May 14, 2003·Annals of Nutrition & Metabolism·Lars OvesenJette Jakobsen
Jun 29, 2004·Journal of the Society for Gynecologic Investigation·Katie N EvansMartin Hewison
Nov 25, 2004·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Eileen R Fowles
Dec 9, 2004·The American Journal of Clinical Nutrition·Mona S CalvoCurtis N Barton
Nov 2, 2006·Obstetrics and Gynecology·Jorge E ChavarroWalter C Willett
Nov 3, 2006·The Journal of Steroid Biochemistry and Molecular Biology·Euclides AvilaFernando Larrea
Jan 8, 2008·Lancet·Robert L GoldenbergRoberto Romero
Jul 6, 2010·Journal of Pediatric Gastroenterology and Nutrition·Enrico BertinoSilvano Milani
Sep 25, 2010·Placenta·J S ShinD M Nelson
Mar 19, 2011·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Michael F Holick
Apr 19, 2011·Lancet·Joy E LawnUNKNOWN Lancet's Stillbirths Series steering committee
May 7, 2011·American Journal of Medical Genetics. Part a·Geeta K SwamyAllison E Ashley-Koch
Sep 22, 2011·Journal of Pediatric Endocrinology & Metabolism : JPEM·Liliana SilvanoUNKNOWN Collaborating Group of Hospital de Niños de la Santísima Trinidad
Apr 17, 2012·Archives of Biochemistry and Biophysics·Yongji WangHector F DeLuca
Jul 7, 2012·Paediatric and Perinatal Epidemiology·Andrew Thorne-Lyman, Wafaie W Fawzi
Nov 28, 2012·Annals of Nutrition & Metabolism·Anthony W Norman
Oct 8, 2013·American Journal of Obstetrics and Gynecology·Timothy P YorkJerome F Strauss
Jan 1, 2013·Reproductive Health·Christopher P HowsonUNKNOWN Born Too Soon Preterm Birth Action Group
Apr 8, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Lauren ManzonSorina Grisaru-Granovsky
Jul 16, 2014·Health Technology Assessment : HTA·Nicholas C HarveyCyrus Cooper
Jun 27, 2015·Nestlé Nutrition Institute Workshop Series·Robert E Black
Mar 5, 2016·European Journal of Clinical Nutrition·S KarrasD G Goulis
Jun 30, 2016·São Paulo Medical Journal = Revista Paulista De Medicina·Luz Maria De-RegilJuan Pablo Peña-Rosas
Feb 6, 2017·Placenta·Tsegaselassie WorkalemahuDaniel A Enquobahrie
Jun 7, 2017·American Journal of Reproductive Immunology : AJRI·Jin-Lu JiAi-Hua Liao
Jun 15, 2017·Archives of Gynecology and Obstetrics·Talya RosenfeldRuth Birk
Jun 18, 2017·Therapeutic Advances in Musculoskeletal Disease·Mairead KielyKaren M O'Callaghan
Sep 9, 2017·International Journal of Genomics·Martina BarchittaAntonella Agodi
Sep 30, 2017·Microbial Ecology in Health and Disease·Alessandra PinoAntonio Cianci
Oct 27, 2017·Metabolism: Clinical and Experimental·Spyridon N KarrasV Daniel Castracane

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Citations

May 10, 2019·American Journal of Human Biology : the Official Journal of the Human Biology Council·Marcos Pereira-SantosAna M Oliveira
Jan 23, 2020·International Journal of Environmental Research and Public Health·Martina BarchittaAntonella Agodi
Feb 23, 2020·Autism Research : Official Journal of the International Society for Autism Research·Franca Rosa GueriniMario Clerici
Jul 30, 2020·Medicina·Andrea Maugeri, Martina Barchitta
Aug 12, 2019·BMJ Open·Debora Farias Batista LeiteJose Guilherme Cecatti
Aug 21, 2019·International Journal of Environmental Research and Public Health·Andrea MaugeriAntonella Agodi
Jan 2, 2020·BMC Pregnancy and Childbirth·Letícia Veríssimo DutraBianca Bianco
Apr 29, 2020·International Journal of Environmental Research and Public Health·Hsin-Liang LiuKuan-Ting Liu
Mar 7, 2021·Vaccines·Martina BarchittaAntonella Agodi
Mar 13, 2021·Journal of Medical Internet Research·Michele ZanettiMaurizio Bonati
Jun 3, 2021·International Journal of Environmental Research and Public Health·Andrea MaugeriAntonella Agodi
Nov 25, 2020·Annals of Nutrition & Metabolism·Carol L Wagner, Bruce W Hollis
Feb 27, 2021·Scientific Reports·Hubert WolskiAgnieszka Seremak-Mrozikiewicz

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Methods Mentioned

BETA
SGA
Genotyping
PCR

Software Mentioned

Epi
SPSS
Review Manager
[UNK]

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