PMID: 6987859Apr 1, 1980Paper

Single nutrient deficiency and cell-mediated immune responses. I. Zinc

The American Journal of Clinical Nutrition
R K Chandra, B Au


The thymus of rats provided zinc-deficient diet weighed less than the thymus of animals fed zinc-containing control diet. The antibody-forming cell response in the spleen was reduced. Cytotoxic response of spleen cells of zinc-deficient mice immunized in vivo was decreased whereas after sensitization in vitro the response was comparable to that seen in zinc-replete animals. Natural killer cell activity and antibody-dependent cell-mediated cytotoxicity were increased, particularly the former. These observations suggest that dietary zinc intake is an important factor modulating cell-mediated immune responses.


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