Jan 27, 2005

Single or multiple small subarachnoid hemorrhages by puncturing a small branch of the rat basilar artery causes chronic cerebral vasospasm

K TureyenE Korfali


This study looked at the effects of single and multiple small subarachnoid hemorrhage (SAH) caused by puncturing a small branch of the basilar artery in rats. Rats were subjected to single SAH (n = 21), multiple SAH (n = 21), sham operation (n = 21), or no procedures (control group, n = 7). SAH was induced in rats by transclival puncture of a small branch of the basilar artery. In the multiple-SAH hemorrhage groups, three small hemorrhages were produced in the same artery at three different times (initial and 24 and 48 h). In the single-SAH groups, one small hemorrhage was produced. Measurements of local cerebral blood flow (LCBF) were made at the initial SAH procedure and at three different time points. Seven animals from each general grouping were killed on Days 4, 10, and 14 (after LCBF was measured). Three different levels of the basilar artery were examined in each animal. Luminal area and arterial wall thickness were measured, and the findings were compared with control and corresponding sham group findings. LCBF dropped dramatically (by 40%) immediately after SAH and reached levels near baseline within 15 minutes (n = 42) (P < 0.001). LCBF continued to drop after initial SAH and reached the lowest level on Day 10 (P < 0....Continue Reading

  • References17
  • Citations8


  • References17
  • Citations8


Mentioned in this Paper

Cerebral Blood Flow Imaging
Arterial System
Salicylhydroxamic acid
Subarachnoid Hemorrhage, Spontaneous
Chronic Disease
Cerebral Vasospasm
Vasospasm, Intracranial
Puncture Procedure
Blood Flow

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