Single particles as resonators for thermomechanical analysis.

Nature Communications
Peter Ouma OkeyoAnja Boisen

Abstract

Thermal methods are indispensable for the characterization of most materials. However, the existing methods require bulk amounts for analysis and give an averaged response of a material. This can be especially challenging in a biomedical setting, where only very limited amounts of material are initially available. Nano- and microelectromechanical systems (NEMS/MEMS) offer the possibility of conducting thermal analysis on small amounts of materials in the nano-microgram range, but cleanroom fabricated resonators are required. Here, we report the use of single drug and collagen particles as micro mechanical resonators, thereby eliminating the need for cleanroom fabrication. Furthermore, the proposed method reveals additional thermal transitions that are undetected by standard thermal methods and provide the possibility of understanding fundamental changes in the mechanical properties of the materials during thermal cycling. This method is applicable to a variety of different materials and opens the door to fundamental mechanistic insights.

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Citations

Mar 30, 2021·ACS Omega·Nikolaj Kofoed MandsbergEn Te Hwu
Jul 3, 2021·Micromachines·Lei WeiXiaodong Wang

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Methods Mentioned

BETA
differential scanning calorimetry
X-ray
light scattering
thermal stress

Software Mentioned

AutoDesk Inventor Professional
LDV
TA Universal Analysis
MATLAB
Polytec vibrometer
’ Pert Data Collector
TRIOS

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