Single polymer studies of hydrophobic hydration

Accounts of Chemical Research
Isaac T S Li, Gilbert C Walker

Abstract

Hydrophobic interactions guide protein folding, multidomain protein assembly, receptor-ligand binding, membrane formation, and cellular transportation. On the macroscale, hydrophobic interactions consist of the aggregation of "oil-like" objects in water by minimizing the interfacial energy. However, studies of the hydration behavior of small hydrophobic molecules have shown that the microscopic (~1 nm) hydration mechanism differs fundamentally from its macroscopic counterpart. Theoretical studies over the last two decades have pointed to an intricate dependence of molecular hydration mechanisms on the length scale. The microscopic-to-macroscopic crossover length scale is critically important to hydrophobic interactions in polymers, proteins, and other macromolecules. Accurate experimental determination of hydration mechanisms and interaction strengths directly influence our understanding of protein folding. In this Account, we discuss our recent measurements of the hydration energies of single hydrophobic homopolymers as they unfold. We describe in detail our single molecule force spectroscopy technique, the interpretation of the single polymer force curve, and how it relates to the hydration free energy of a hydrophobic polyme...Continue Reading

References

Apr 1, 1995·Protein Science : a Publication of the Protein Society·K A DillH S Chan
Dec 1, 1995·Protein Science : a Publication of the Protein Society·N G OikonomakosK R Acharya
Jul 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·D M Huang, D Chandler
Aug 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·G HummerL R Pratt
May 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·Pieter Rein ten Wolde, David Chandler
Mar 14, 2003·Physical Review Letters·D MarenduzzoF Seno
Mar 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yaakov Levy, José N Onuchic
May 5, 2005·Annual Review of Biophysics and Biomolecular Structure·Ken A DillBarbara Hribar-Lee
Jun 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sowmianarayanan RajamaniShekhar Garde
Nov 15, 2005·Chemical Society Reviews·Siegfried Höfinger, Francesco Zerbetto
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C Tanford
May 20, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jason A Wagoner, Nathan A Baker
Sep 1, 2006·The Journal of Physical Chemistry. B·Chad RayBoris B Akhremitchev
Jan 12, 2007·Proceedings of the National Academy of Sciences of the United States of America·Manoj V AthawaleShekhar Garde
Jun 22, 2007·Journal of Molecular Biology·Robert L Baldwin
Aug 2, 2007·Journal of the American Chemical Society·Nikhil GunariGilbert C Walker
Jun 17, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Esben ThormannOle G Mouritsen
Jul 4, 2008·Journal of the American Chemical Society·Chad RayBoris B Akhremitchev
Jul 16, 2008·Journal of the American Chemical Society·Johan Qvist, Bertil Halle
Aug 13, 2008·Journal of the American Chemical Society·Frauke GräterB J Berne
Aug 20, 2008·Accounts of Chemical Research·Dor Ben-Amotz, Robin Underwood
Oct 22, 2008·Annual Review of Physical Chemistry·Bruce J BerneRuhong Zhou
Jun 6, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Sumanth N JamadagniShekhar Garde
Aug 18, 2009·Accounts of Chemical Research·Artem A BakulinMaxim S Pshenichnikov
Oct 13, 2009·International Journal of Pharmaceutics·Parijat Jain, Samuel H Yalkowsky
Apr 22, 2010·Journal of the American Chemical Society·Isaac T S Li, Gilbert C Walker
Jun 18, 2010·The Journal of Physical Chemistry. B·Robin UnderwoodDor Ben-Amotz
Nov 4, 2010·Faraday Discussions·Peter J Rossky
Feb 2, 2011·The Journal of Chemical Physics·F BiscayP Malfreyt
Sep 14, 2011·Proceedings of the National Academy of Sciences of the United States of America·Isaac T S Li, Gilbert C Walker
Jan 1, 2011·Annual Review of Chemical and Biomolecular Engineering·Sumanth N JamadagniShekhar Garde

❮ Previous
Next ❯

Citations

Feb 26, 2013·Journal of the American Chemical Society·Luis M NegrónJosé M Rivera
Jul 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Jagannath MondalBruce J Berne
May 4, 2016·Chemical Reviews·Frank Biedermann, Hans-Jörg Schneider
May 25, 2016·Annual Review of Physical Chemistry·Dor Ben-Amotz
Jun 28, 2016·Advances in Colloid and Interface Science·Zhijian WuJan D Miller
Mar 17, 2017·Annual Review of Physical Chemistry·Elnaz AlipourGilbert C Walker
May 18, 2016·Journal of Computational Chemistry·Maria M Reif, Martin Zacharias
Aug 26, 2016·Physical Chemistry Chemical Physics : PCCP·Shannon R PattenaudeDor Ben-Amotz
Apr 13, 2013·Physical Chemistry Chemical Physics : PCCP·Giuseppe Graziano
Sep 10, 2019·Biopolymers·Sutapa DuttaJaydeb Chakrabarti
May 16, 2020·Physical Chemistry Chemical Physics : PCCP·Aria J Bredt, Dor Ben-Amotz
Aug 11, 2020·Frontiers in Chemistry·Wenbo ZhangChenxuan Wang
Oct 31, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Kai LiuXi Zhang
Jan 23, 2018·Journal of the American Chemical Society·Stephan SinnLuisa De Cola
Apr 11, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Yiran LiWei Wang
Oct 31, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Yuechao TangQingxia Liu
Aug 9, 2013·The Journal of Physical Chemistry. B·Cécile BerneBogdan Dragnea
Nov 22, 2014·The Journal of Physical Chemistry. B·Joel G DavisDor Ben-Amotz
Mar 3, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Bin Meng, Henry S Ashbaugh
Feb 9, 2018·The Journal of Physical Chemistry Letters·Xiangen WuDor Ben-Amotz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Isaac T S Li, Gilbert C Walker
Proceedings of the National Academy of Sciences of the United States of America
Shekhar Garde, Amish J Patel
Physical Chemistry Chemical Physics : PCCP
Giuseppe Graziano
Proceedings of the National Academy of Sciences of the United States of America
Amish J PatelDavid Chandler
© 2021 Meta ULC. All rights reserved