Single-prolonged stress induced mitochondrial-dependent apoptosis in hippocampus in the rat model of post-traumatic stress disorder

Journal of Chemical Neuroanatomy
Xiaoming LiYuxiu Shi

Abstract

Post-traumatic stress disorder (PTSD) is a stress-related mental disorder caused by experience of a traumatic event, and presents with characteristic symptoms including intrusive memories, hyperarousal, and avoidance. Recently, structural neuroimaging studies showed that hippocampal volumes were relatively low in PTSD patients. However, the mechanisms that cause such atrophy are not well understood. The aim of this study was to reveal the possible mechanisms involved in apoptosis induced by single-prolonged stress (SPS) in hippocampus of PTSD rats. SPS is one of the animal models proposed for PTSD. Rats exposure to SPS showed enhanced inhibition of the hypothalamo-pituitary-adrenal (HPA) axis, which has been reliably reproduced in patients with PTSD. Wistar rats were killed at 1, 4, 7, 14 and 28 days after exposure to SPS. Expression of caspase-9, caspase-3, cytochrome c, Bcl-2 and Bax was detected by immunohistochemistry, immunofluorescence, Western blotting and electron microscopy. Apoptotic cells were assessed by TUNEL method. Our results showed apoptotic cells were significantly increased in hippocampus of SPS rats, accompanied by release of cytochrome c from the mitochondria into the cytosol, increase of caspase-9 and casp...Continue Reading

References

Mar 1, 1991·Archives of General Psychiatry·N BreslauE Peterson
Sep 1, 1987·Journal of Microscopy·H J Gundersen, E B Jensen
Jun 21, 1997·Annals of the New York Academy of Sciences·A M Rasmusson, D S Charney
Aug 28, 1998·Science·N A Thornberry, Y Lazebnik
Mar 26, 2003·Cell Death and Differentiation·M E Peter, P H Krammer
Jul 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·H YamasueN Kato
Sep 15, 2004·Journal of Chemical Neuroanatomy·Takashi Momoi
Dec 4, 2004·Biological Psychiatry·Emma L WignallPeter W R Woodruff
Aug 27, 2005·Journal of Chemical Neuroanatomy·Alexander SemmlerMichael T Heneka
Jun 9, 2006·Differentiation; Research in Biological Diversity·Qin YanDavid Wan-Cheng Li
Aug 17, 2006·Leukemia Research·Joanna SkommerAndrzej Deptala
Oct 28, 2006·Neurobiology of Disease·Rachel KarlnoskiGiulio Taglialatela
Dec 13, 2006·Neurobiology of Disease·Cornelia FrankeGunter P Eckert
Nov 14, 2007·Acta Psychiatrica Scandinavica·W V R ViewegA K Pandurangi
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·John G WalshSeamus J Martin

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Citations

Jan 15, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Huang NieQingrong Tan
Dec 10, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Hiroyuki OtabeKunio Shimizu
Mar 19, 2019·PloS One·Synthia H MellonOwen M Wolkowitz
Jan 15, 2020·Journal of Molecular Neuroscience : MN·Wei ShanYuxiu Shi
May 12, 2017·Frontiers in Behavioral Neuroscience·Fang HanYuxiu Shi
Jul 30, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Mahboobeh Ghasemzadeh Rahbardar, Hossein Hosseinzadeh
Jul 29, 2017·Journal of Molecular Neuroscience : MN·Jiangang WangYuxiu Shi
Apr 10, 2017·Apoptosis : an International Journal on Programmed Cell Death·Lili WenFang Han
Sep 29, 2017·Frontiers in Pharmacology·Rimenez R SouzaChrista K McIntyre
Nov 13, 2019·Behavioural Brain Research·Karem H AlzoubiMahmoud A Alfaqih
Apr 10, 2018·Biological Psychiatry·Synthia H MellonOwen M Wolkowitz
Apr 6, 2021·Frontiers in Cell and Developmental Biology·Emily T StonehamTheodore C Dumas

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