Single-pulse transcranial magnetic stimulation of parietal and prefrontal areas in a memory delay arm pointing task

Journal of Neurophysiology
Nikolaos SmyrnisNikos Karandreas

Abstract

Fifteen healthy volunteers performed a memory-pointing task using their right arm while single-pulse transcranial magnetic stimulation (TMS) above motor threshold was applied over the posterior parietal or prefrontal cortex of the left or right hemisphere in four blocks of trials. The stimulation was randomly delivered at one of three time intervals during the 3-s delay period (early: 300 ms, intermediate: 1,500 ms, late: 2,700 ms). A separate block with no stimulation was used as control. Only early left parietal stimulation resulted in an increase in the variance of movement amplitude but not direction for all targets in two-dimensional space (both hemifields). The results point to the significance of the contralateral posterior parietal cortex early on during the memorization of the target for an upcoming movement. Taking into consideration the limitations of TMS and those imposed by the particular task, the lack of specific effects of prefrontal stimulation provides evidence that these areas might not be involved in the performance of simple memorized arm movements.

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Citations

Jul 11, 2012·Experimental Brain Research·Michael Vesia, J Douglas Crawford
Apr 15, 2005·Journal of Cognitive Neuroscience·Marc Himmelbach, Hans-Otto Karnath
Sep 17, 2013·PloS One·Anthony SinghalJody C Culham
Aug 18, 2004·Behavioural Brain Research·Boris SuchanVolker Hömberg
Feb 4, 2006·Neuropsychologia·M F S Rushworth, P C J Taylor
May 12, 2009·Neuropsychologia·Marc HimmelbachHans-Otto Karnath
May 5, 2011·Neuropsychologia·Christopher L StriemerMelvyn A Goodale
Sep 19, 2007·Arquivos de neuro-psiquiatria·Julio Guilherme SilvaPedro Ribeiro
Aug 2, 2005·Arquivos de neuro-psiquiatria·Dionis MachadoPedro Ribeiro
Aug 2, 2005·Arquivos de neuro-psiquiatria·Victor Hugo BastosPedro Ribeiro
Aug 19, 2006·Arquivos de neuro-psiquiatria·Julio Guilherme SilvaPedro Ribeiro
Aug 19, 2006·Arquivos de neuro-psiquiatria·Claudio Elidio PortellaPedro Ribeiro

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