Single scan quantitative gradient recalled echo MRI for evaluation of tissue damage in lesions and normal appearing gray and white matter in multiple sclerosis

Journal of Magnetic Resonance Imaging : JMRI
Biao XiangDmitriy A Yablonskiy

Abstract

Multiple sclerosis (MS) is a chronic disease affecting the human central nervous system (CNS) and leading to neurologic disability. Although conventional MRI techniques can readily detect focal white matter (WM) lesions, it remains challenging to quantify tissue damage in normal-appearing gray matter (GM) and WM. To demonstrate that a new MRI biomarker, R2t*, can provide quantitative analysis of tissue damage across the brain in MS patients in a single scan. Prospective. Forty-four MS patients and 19 healthy controls (HC). 3T, quantitative gradient-recalled-echo (qGRE), Magnetization-prepared rapid gradient-echo, fluid-attenuated inversion recovery. Severity of tissue damage was assessed by reduced R2t*. Tissue atrophy was assessed by cortical thickness and cervical spinal cord cross-sectional area (CSA). Multiple Sclerosis Functional Composite was used for clinical assessment. R2t* in cortical GM was more sensitive to MS damage than cortical atrophy. Using more than two standard deviations (SD) reduction versus age-matched HC as the cutoff, 48% of MS patients showed lower R2t*, versus only 9% with lower cortical thickness. Significant correlations between severities of tissue injury were identified among 1) upper cervical cord...Continue Reading

References

Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S OgawaD W Tank
Jul 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J P Mugler, J R Brookeman
Dec 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D A Yablonskiy, E M Haacke
Jun 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A MacKayD Graeb
Mar 14, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D A Yablonskiy
May 14, 2003·Neurology·M P SormaniUNKNOWN European Study Group on Interferon Beta-1b in Secondary Progressive MS
Aug 7, 2003·Journal of Neuropathology and Experimental Neurology·Lars BøSverre J Mørk
Nov 16, 2005·Archives of Neurology·Robert T Naismith, Anne H Cross
Apr 13, 2007·Annals of Neurology·Elizabeth FisherBruce D Trapp
May 13, 2009·Archives of Neurology·Alexandra SeewannJeroen J G Geurts
Oct 1, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Shannon H Kolind, Sean C Deoni
Dec 13, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Dmitriy A YablonskiyXiaoqi Wang
Feb 5, 2013·Annals of Neurology·Robert A BermelRichard A Rudick
Feb 1, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jie WenDmitriy A Yablonskiy
Feb 15, 2015·Brain : a Journal of Neurology·Caterina MaineroRevere P Kinkel
Mar 11, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xialing Ulrich, Dmitriy A Yablonskiy
Dec 8, 2015·Brain : a Journal of Neurology·Martijn D SteenwijkPetra J W Pouwels
Oct 11, 2016·NeuroImage·Benjamin De LeenerJulien Cohen-Adad
Sep 24, 2015·Multiple Sclerosis Journal - Experimental, Translational and Clinical·Kevin R PatelAnne H Cross

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Citations

May 6, 2020·Annals of Clinical and Translational Neurology·Biao XiangAnne H Cross
May 5, 2021·Annals of Clinical and Translational Neurology·Matthew R BrierRobert T Naismith

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