Single segment of spleen autotransplantation, after splenectomy for trauma, can restore splenic functions.

World Journal of Emergency Surgery : WJES
Adriana ToroIsidoro Di Carlo

Abstract

Splenectomy is sometimes necessary after abdominal trauma, but splenectomized patients are at risk of sepsis due to impaired immunological functions. To overcome this risk, autotransplantation of the spleen by using a new technique has been proposed, but so far, a demonstration of functionality of the transplanted tissue is lacking. We therefore evaluated 5 patients who underwent a splenic autotransplant in comparison with 5 splenectomized patients without splenic autotransplant and 7 normal subjects. We confirmed that the patients not undergoing autotransplantation, when compared to normal subjects, had a higher platelet count, higher percentage of micronucleated reticulocytes (p = 0.002), increased levels of naive B lymphocytes (p = 0.01), a defect of class-switched memory (p = 0.001) and class-unswitched memory B cells (p = 0.002), and increased levels of PD1 on T lymphocytes CD8+ (p = 0.08). In contrast, no significant differences for any of the abovementioned parameters were recorded between patients who underwent spleen autotransplantation and normal subjects. These findings suggest that splenic autotransplantation is able to restore an adequate hemocatheretic activity as well as recover the immunological deficit after sp...Continue Reading

References

Apr 1, 1977·The Australian and New Zealand Journal of Surgery·T P JosephJ P Savage
Mar 1, 1991·The British Journal of Surgery·R J Holdsworth
Apr 12, 2003·The Journal of Experimental Medicine·Stephanie KruetzmannRita Carsetti
Jun 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stuart G Tangye, Kim L Good
Feb 9, 2008·Seminars in Immunology·Iñaki SanzJennifer Anolik
Jul 20, 2010·Immunological Reviews·Loise M FranciscoArlene H Sharpe
Sep 4, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kim L Good-Jacobson, Mark J Shlomchik
Aug 17, 2011·Journal of Medical Case Reports·Adriana ToroIsidoro Di Carlo
Sep 20, 2011·Surgical Innovation·Isidoro Di CarloAdriana Toro
Sep 4, 2015·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·Moamena El-MatboulyHassan Al-Thani
Jan 4, 2017·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Isidoro Di Carlo, Adriana Toro
Nov 30, 2018·Immunology·Rachel Wong, Deepta Bhattacharya

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

© 2021 Meta ULC. All rights reserved