Single-Session Bronchial Thermoplasty Guided by 129Xe Magnetic Resonance Imaging. A Pilot Randomized Controlled Clinical Trial.

American Journal of Respiratory and Critical Care Medicine
Chase S HallMario Castro

Abstract

Rationale: Adverse events have limited the use of bronchial thermoplasty (BT) in severe asthma.Objectives: We sought to evaluate the effectiveness and safety of using 129Xe magnetic resonance imaging (129Xe MRI) to prioritize the most involved airways for guided BT.Methods: Thirty subjects with severe asthma were imaged with volumetric computed tomography and 129Xe MRI to quantitate segmental ventilation defects. Subjects were randomized to treatment of the six most involved airways in the first session (guided group) or a standard three-session BT (unguided). The primary outcome was the change in Asthma Quality of Life Questionnaire score from baseline to 12 weeks after the first BT for the guided group compared with after three treatments for the unguided group.Measurements and Main Results: There was no significant difference in quality of life after one guided compared with three unguided BTs (change in Asthma Quality of Life Questionnaire guided = 0.91 [95% confidence interval, 0.28-1.53]; unguided = 1.49 [95% confidence interval, 0.84-2.14]; P = 0.201). After one BT, the guided group had a greater reduction in the percentage of poorly and nonventilated lung from baseline when compared with unguided (-17.2%; P = 0.009). Th...Continue Reading

References

Jan 1, 1994·Journal of Clinical Epidemiology·E F JuniperL E Griffith
Nov 2, 2006·Current Medical Research and Opinion·Bradley ChippsColin Reisner
Mar 7, 2009·The New England Journal of Medicine·Pranabashis HaldarIan D Pavord
Sep 22, 2009·The Journal of Allergy and Clinical Immunology·Michael SchatzPriti Jhingran
Oct 10, 2009·American Journal of Respiratory and Critical Care Medicine·Mario CastroUNKNOWN AIR2 Trial Study Group
Apr 10, 2010·IEEE Transactions on Medical Imaging·Nicholas J TustisonJames C Gee
Nov 26, 2010·Journal of Magnetic Resonance Imaging : JMRI·Ravi AysolaTalissa A Altes
Aug 13, 2011·Journal of Magnetic Resonance Imaging : JMRI·Nicholas J TustisonJames C Gee
Apr 17, 2013·Journal of Magnetic Resonance Imaging : JMRI·Sarah SvenningsenGrace Parraga
Aug 21, 2013·Thorax·Sarah SvenningsenGrace Parraga
Sep 4, 2013·The Journal of Allergy and Clinical Immunology·Michael E WechslerUNKNOWN Asthma Intervention Research 2 Trial Study Group
Dec 18, 2013·The European Respiratory Journal·Kian Fan ChungW Gerald Teague
Dec 17, 2014·American Journal of Respiratory and Critical Care Medicine·Marina PretolaniMichel Aubier
Nov 2, 2015·The Journal of Allergy and Clinical Immunology·Talissa A AltesW Gerald Teague
May 14, 2016·The European Respiratory Journal·Sarah SvenningsenGrace Parraga
Aug 2, 2016·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Robert P ThomenJason C Woods
Aug 3, 2016·American Journal of Respiratory and Critical Care Medicine·Jered P SierenUNKNOWN SPIROMICS Research Group
Jan 10, 2017·The Journal of Allergy and Clinical Immunology·Abhaya TrivediMario Castro
Jul 6, 2017·Respiratory Research·David LangtonVirginia Plummer
Nov 14, 2017·The Journal of Allergy and Clinical Immunology·David G MummySean B Fain
Apr 19, 2018·American Journal of Respiratory Cell and Molecular Biology·Graham M DonovanPeter B Noble
May 22, 2018·The New England Journal of Medicine·Mario CastroAriel Teper
Dec 12, 2018·American Journal of Respiratory and Critical Care Medicine·Mary Clare McGregorMario Castro
Dec 13, 2018·American Journal of Respiratory and Critical Care Medicine·Ikhlass Haj SalemJamila Chakir

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Citations

Nov 27, 2020·The British Journal of Radiology·James G KringsMario Castro
Dec 3, 2020·ERJ Open Research·David LangtonGraham M Donovan
Nov 18, 2020·Clinical Medicine : Journal of the Royal College of Physicians of London·Carmen VenegasParameswaran Nair
Feb 27, 2021·Progress in Nuclear Magnetic Resonance Spectroscopy·Helen MarshallJim M Wild
Mar 6, 2021·The Journal of Allergy and Clinical Immunology·Mario Castro, Geoffrey Chupp
Feb 26, 2021·Journal of Applied Physiology·David LangtonGraham M Donovan
Nov 24, 2020·The Journal of Allergy and Clinical Immunology·Nancy Y LinJason C Woods
Jun 8, 2021·The Journal of Allergy and Clinical Immunology·Blanca Camoretti-Mercado, Richard F Lockey
Jun 10, 2021·The British Journal of Radiology·Neil J StewartJim M Wild
Jun 29, 2021·American Journal of Respiratory and Critical Care Medicine·Andrew J HalaykoPrescott G Woodruff
Aug 20, 2021·Journal of Asthma and Allergy·Joseph W Lanario, Lorna Burns
Sep 4, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peter J NiedbalskiJason C Woods
Sep 18, 2021·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Daniel B GreenEugene Shostak
Oct 14, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peter J NiedbalskiBastiaan Driehuys
Nov 2, 2021·Current Opinion in Pulmonary Medicine·Justin L Garner, Pallav L Shah
Jan 11, 2022·Respirology : Official Journal of the Asian Pacific Society of Respirology·Harkiran K KoonerGrace Parraga

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Methods Mentioned

BETA
sedation
imaging technique

Clinical Trials Mentioned

NCT01832363

Software Mentioned

Apollo
SAS

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