Single session stereotactic radiosurgery boost to the post-operative site in lieu of whole brain radiation in metastatic brain disease

Journal of Neuro-oncology
Matthew R QuigleyMark Johnson

Abstract

Whole brain radiation (WBXRT) reduces the incidence of local and distant recurrence following resection of metastatic brain disease but does not prolong life and may entail neurocognitive decline. We employed a novel treatment modality of providing a single-session stereotactic radiosurgery (SRS) boost to the surgical resection site to achieve local control without the risk of cognitive effects. We reviewed all patients at our institution that were treated with SRS to the post-operative bed following resection of a metastatic brain deposit. There were 32 patients identified (16 F) and median age was 60 years. One lesion was resected in all patients of whom 21 were solitary (eight with two lesions, three with three). Median survival was 16.4 months with a 14 month median follow-up. Factors which improved survival were solitary tumor, age <65 and RPA 1, although none achieved statistical significance. In the Cox multivariate analysis only smaller post-operative treatment volume correlated with survival (P = .04). There were two local recurrences (6.25%) to the surgical site and four patients required SRS for new lesions. Nine patients ultimately required salvage WBXRT (3/21 solitary v. 6/11 multiple lesions, P = .03 chi(2)), two ...Continue Reading

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Citations

Jul 5, 2019·Current Oncology Reports·Cristian UdovicichNeda Haghighi
Mar 14, 2020·Journal of Magnetic Resonance Imaging : JMRI·Min ZhangXiaoyin Xu
Nov 30, 2011·Current Opinion in Supportive and Palliative Care·May N TsaoMinesh P Mehta
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Apr 26, 2015·Journal of Neuro-oncology·Mark J AmsbaughShiao Woo
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