Single-shot detection of bacterial endospores via coherent Raman spectroscopy

Proceedings of the National Academy of Sciences of the United States of America
Dmitry PestovMarlan Scully

Abstract

Recent advances in coherent Raman spectroscopy hold exciting promise for many potential applications. For example, a technique, mitigating the nonresonant four-wave-mixing noise while maximizing the Raman-resonant signal, has been developed and applied to the problem of real-time detection of bacterial endospores. After a brief review of the technique essentials, we show how extensions of our earlier experimental work [Pestov D, et al. (2007) Science 316:265-268] yield single-shot identification of a small sample of Bacillus subtilis endospores (approximately 10(4) spores). The results convey the utility of the technique and its potential for "on-the-fly" detection of biohazards, such as Bacillus anthracis. The application of optimized coherent anti-Stokes Raman scattering scheme to problems requiring chemical specificity and short signal acquisition times is demonstrated.

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Citations

Feb 27, 2010·Proceedings of the National Academy of Sciences of the United States of America·Saar Rahav, Shaul Mukamel
Jan 5, 2012·Proceedings of the National Academy of Sciences of the United States of America·Rajan AroraMarlan O Scully
Sep 4, 2009·Journal of Modern Optics·Rajan AroraVladislav V Yakovlev
May 3, 2012·The Journal of Antimicrobial Chemotherapy·Xiaonan LuMichael E Konkel
Mar 9, 2010·Applied and Environmental Microbiology·S StöckelJ Popp
Nov 13, 2008·Annual Review of Physical Chemistry·Yaron Silberberg
Jul 4, 2013·Investigative Ophthalmology & Visual Science·David A AmmarOmid Masihzadeh
Aug 13, 2014·Proceedings of the National Academy of Sciences of the United States of America·Brett H HokrMarlan O Scully
Nov 22, 2008·Journal of Biomedical Optics·Arthur DogariuMarlan O Scully
Apr 15, 2015·Advanced Drug Delivery Reviews·Amrit PaudelJukka Rantanen
Oct 21, 2010·Biophysical Journal·Sapun H ParekhMarcus T Cicerone
May 23, 2016·The Journal of Chemical Physics·Maxim F Gelin, Wolfgang Domcke
Feb 12, 2019·Scientific Reports·Benjamin D StryckerMarlan O Scully
Aug 15, 2018·Cold Spring Harbor Perspectives in Medicine·Kaiyu FuPaul W Bohn
Jul 17, 2014·The Analyst·Graeme ClemensMatthew J Baker
Nov 29, 2012·Scientific Reports·Dmitri V VoronineMarlan O Scully
Apr 19, 2013·Optics Letters·J I JangM G Kanatzidis
Dec 21, 2013·Laser & Photonics Reviews·Haohua Tu, Stephen A Boppart
Mar 4, 2020·Optics Express·Edoardo VicentiniNicola Coluccelli
Mar 16, 2017·Proceedings of the National Academy of Sciences of the United States of America·Narangerel AltangerelMarlan O Scully
Sep 1, 2018·Light, Science & Applications·Diana Serrano, Stefan Seeger
Feb 6, 2018·Applied Optics·Alexey ShchekinYoung-Geun Roh
Jun 6, 2019·Optics Express·Tuguldur Kh BegzjavGirish S Agarwal
Aug 24, 2017·Scientific Reports·Jeremy N KunzMarlan O Scully
Jan 1, 2017·Journal of Analysis and Testing·Jiayun Hu, Paul W Bohn
Feb 27, 2018·Physical Review Letters·Andrew J TraversoVladislav V Yakovlev
Sep 22, 2011·Angewandte Chemie·In ChungMercouri G Kanatzidis
Nov 3, 2020·Optics Letters·Edoardo VicentiniNicola Coluccelli
Dec 17, 2009·Journal of the American Chemical Society·In ChungMercouri G Kanatzidis

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