Single-step detection of norovirus tuning localized surface plasmon resonance-induced optical signal between gold nanoparticles and quantum dots

Biosensors & Bioelectronics
Fahmida NasrinEnoch Y Park

Abstract

A new method of label free sensing approach with superior selectivity and sensitivity towards virlabel-freeon is presented here, employing the localized surface plasmon resonance (LSPR) behavior of gold nanoparticles (AuNPs) and fluorescent CdSeTeS quantum dots (QDs). Inorganic quaternary alloyed CdSeTeS QDs were capped with L-cysteine via a ligand exchange reaction. Alternatively, citrate stabilized AuNPs were functionalized with 11-mercaptoundecanoic acid to generate carboxylic group on the gold surface. The carboxylic group on the AuNPs was subjected to bind covalently with the amine group of L-cysteine capped CdSeTeS QDs to form CdSeTeS QDs/AuNPs nanocomposites. The fluorescence of CdSeTeS QDs/AuNPs nanocomposite shows quenched spectrum of CdSeTeS QDs at 640 nm due to the close interaction with AuNPs. However, after successive addition of norovirus-like particles (NoV-LPs), steric hindrance-induced LSPR signal from the adjacent AuNPs triggered the fluorescence enhancement of QDs in proportion to the concentration of the target NoV-LPs. A linear range of 10-14 to 10-9 g mL-1 NoV-LPs with a detection limit of 12.1 × 10-15 g mL-1 was obtained. This method was further applied on clinically isolated norovirus detection, in the r...Continue Reading

Citations

Apr 3, 2020·Micromachines·Muqsit Pirzada, Zeynep Altintas
Mar 14, 2020·Foods·Lingling Liu, Matthew D Moore
Feb 8, 2020·Sensors·Marta Janczuk-RichterJoanna Niedziółka Jönsson
Jan 6, 2021·Biosensors·Priya Kishor DaveVatcharapan Umpaichitra
Oct 4, 2020·Biosensors & Bioelectronics·Ankan Dutta ChowdhuryEnoch Y Park
Nov 12, 2020·Advanced Theory and Simulations·Chandreyee Manas DasKen-Tye Yong
Dec 15, 2020·Journal of Hazardous Materials·Mohsen PilevarWoo Hyoung Lee
Apr 1, 2021·Emergent Materials·E Alperay TarimH Cumhur Tekin
Apr 1, 2021·Advanced Photonics Research·Yuzhi ShiAi Qun Liu
Sep 10, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Jianxin WangSeungpyo Hong

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