Single-step synthesis of [18F]haloperidol from the chloro-precursor and its applications in PET imaging of a cat's brain

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
K HashizumeY Miyake

Abstract

We have established a convenient synthesis process for the synthesis of[18F]haloperidol using a single-step 18F-for-Cl exchange reaction and a new elution system for the preparative high performance liquid chromatography (HPLC) using C18 bonded vinylalcohol copolymer gel (ODP) and a basic eluent. We successfully applied the product to cat-PET study and got clear images of the striatum, showing the usefulness of this synthesis.

References

Jan 1, 1991·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·P K Chakraborty, M R Kilbourn
Jan 1, 1990·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·C PascaliJ E Cremer
Jan 1, 1986·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·M S Berridge, T J Tewson
Jul 1, 1984·The International Journal of Applied Radiation and Isotopes·M R KilbournM Maeda

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Citations

Jan 12, 2016·Chemical Reviews·Sean PreshlockVéronique Gouverneur
Nov 7, 2008·Angewandte Chemie·Philip W MillerAntony D Gee
Nov 29, 2013·Journal of Labelled Compounds & Radiopharmaceuticals·Olaf PranteAshutosh Banerjee
Apr 7, 2020·Journal of the American Chemical Society·Liam S SharninghausenMelanie S Sanford

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