Single-Step Synthesis of Small, Azide-Functionalized Gold Nanoparticles: Versatile, Water-Dispersible Reagents for Click Chemistry

Langmuir : the ACS Journal of Surfaces and Colloids
Edward W ElliottJames E Hutchison

Abstract

Nanoparticles possessing functional groups that can be readily conjugated (e.g., through click chemistry) are important precursors for the preparation of customized nanohybrid products. Such nanoparticles, if they are stable against agglomeration, are easily dispersible and have well-defined surface chemistry and size. As click-ready reagents, they can be stored until their time of use and then simply dispersed and reacted with an appropriate substrate. Gold nanoparticles (AuNPs) are excellent candidates for this purpose, and some clickable gold nanoparticles have been developed; however, AuNPs for use in aqueous systems are often prepared through difficult multistep processes and/or can be poorly dispersible in water. Here we report a single-step synthesis of clickable, water-dispersible AuNPs. The synthesis yields uniform, 3.5 nm diameter cores coated with a well-defined molecular ligand shell that makes the AuNPs stable and dispersible in water. The AuNP mixed ligand shell consists of hydroxyl-terminated ethylene glycol-based ligands to promote dispersion in water and a small number of azide-terminated ligands that readily undergo click reactions with alkynes. The use of a mesofluidic reactor affords fine control over the co...Continue Reading

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Citations

Jun 9, 2017·Chemistry, an Asian Journal·Arnaud ChevalierAnthony Romieu
Dec 18, 2020·Organic & Biomolecular Chemistry·Kanna Mori, Kaori Sakurai
Jan 20, 2021·Biotechnology and Applied Biochemistry·Gerardo ZambranoFlavia Nastri
Jul 15, 2021·The Journal of Physical Chemistry. B·Julian SindramMatthias Karg
Dec 29, 2020·The Journal of Physical Chemistry. B·Selina Beatrice van der MeerMatthias Epple
May 2, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Selina Beatrice van der MeerMatthias Epple

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