Single-subject classification of schizophrenia using event-related potentials obtained during auditory and visual oddball paradigms.

European Archives of Psychiatry and Clinical Neuroscience
Andres H NeuhausAnil K Malhotra

Abstract

In the search for the biomarkers of schizophrenia, event-related potential (ERP) deficits obtained by applying the classic oddball paradigm are among the most consistent findings. However, the single-subject classification rate based on these parameters remains to be determined. Here, we present a data-driven approach by applying machine learning classifiers to relevant oddball ERPs. Twenty-four schizophrenic patients and 24 matched healthy controls finished auditory and visual oddball tasks while high-density electrophysiological recordings were applied. The N1 component in response to standards and target as well as the P3 component following targets were submitted to different machine learning algorithms and the resulting ERP features were submitted to further correlation analyses. We obtained a classification accuracy of 72.4 % using only two ERP components. Latencies of parietal N1 components to visual standard stimuli at electrode positions Pz and P1 were sufficient for classification. Further analysis revealed a high correlation of these features in controls and an intermediate correlation in schizophrenia patients. These data exemplarily show how automated inference may be applied to classify a pathological state in sin...Continue Reading

References

May 1, 1990·Electroencephalography and Clinical Neurophysiology·J PolichF E Bloom
Jan 1, 1993·Schizophrenia Bulletin·D L Braff
May 1, 1993·Journal of Affective Disorders·B N GangadharC Umapathy
Jan 23, 1999·Biological Psychiatry·D F SalisburyR W McCarley
Sep 29, 2000·European Archives of Psychiatry and Clinical Neuroscience·G WintererW M Herrmann
Oct 6, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·T P JungT J Sejnowski
Mar 14, 2001·European Psychiatry : the Journal of the Association of European Psychiatrists·M Fichter, N Quadflieg
Jul 6, 2001·Schizophrenia Research·S R SponheimM Beiser
Jun 11, 2003·Schizophrenia Bulletin·John W CarterSarnoff A Mednick
Aug 27, 2004·Schizophrenia Research·Elvira BramonSophia Frangou
Nov 9, 2005·Archives of General Psychiatry·Christos DavatzikosRaquel E Gur
Jun 27, 2006·Schizophrenia Research·Patricia J PardoS Charles Schulz
Sep 21, 2006·Brain : a Journal of Neurology·Pamela D ButlerDaniel C Javitt
Apr 21, 2009·European Archives of Psychiatry and Clinical Neuroscience·Helene Haker, Wulf Rössler
Sep 16, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yoichiro TakayanagiMichio Suzuki
Feb 20, 2010·European Archives of Psychiatry and Clinical Neuroscience·David ZillesOliver Gruber
Aug 25, 2011·European Archives of Psychiatry and Clinical Neuroscience·Birgit Derntl, Ute Habel
Sep 6, 2011·European Archives of Psychiatry and Clinical Neuroscience·Christiane MontagJürgen Gallinat
Feb 24, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Darshan IyerGeorge Zouridakis

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Citations

Mar 5, 2013·European Archives of Psychiatry and Clinical Neuroscience·Andrea Schmitt, Peter Falkai
Jun 11, 2014·Schizophrenia Bulletin·Naoya OribeMargaret Niznikiewicz
Dec 20, 2015·Journal of Neurophysiology·Ann-Kathrin StockChristian Beste
Oct 30, 2018·Frontiers in Integrative Neuroscience·Abdoreza AsadpourSaeid Mahmoudian

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