Single tablet HIV regimens facilitate virologic suppression and retention in care among treatment naïve patients

AIDS Care
Vagish HemmigeTeddy Zerai

Abstract

Newer HIV regimens are typically taken once daily but vary in the number of pills required. Whether the number of pills in a once-daily HIV regimen affects clinical outcomes is unknown. We retrospectively compared adherence, retention in care, and virologic outcomes between patients starting a once daily single-tablet regimen (STR) to patients starting a once-daily multi-tablet regimen (MTR) in a publicly funded clinic in the United States. Outcomes were measured in the year after starting ART and included retention in care, virologic suppression, and medication possession ratio of at least 80%. Data from patients initiating therapy from 1 January 2008 to 31 December 2011 were analyzed with both unadjusted and propensity-score adjusted regression. Overall, 622 patients started with an STR (100% efavirenz-based) and 406 with an MTR (65% atazanavir-based and 35% darunavir-based) regimen. Retention in care was achieved in 80.7% of STR patients vs. 72.7% of MTR patients (unadjusted OR 1.57, 95% CI 1.17-2.11; adjusted OR 1.49, 95% CI 1.10-2.02). Virologic suppression occurred among 84.4% of STR patients vs. 77.6% of MTR patients (unadjusted OR 1.56; 95% CI 1.14-2.15; adjusted OR 1.41; 95% CI 1.02-1.96). There was no difference in th...Continue Reading

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Citations

Jan 25, 2019·Expert Opinion on Pharmacotherapy·Amedeo Capetti, Giuliano Rizzardini
Jun 19, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Vagish HemmigeThomas P Giordano
Jan 31, 2020·The Nurse Practitioner·Jeffrey Kwong
Oct 27, 2018·Open Forum Infectious Diseases·Caroline B DerrickNathan M Thielman
Feb 13, 2020·AIDS Patient Care and STDs·Juliana de Oliveira CostaSallie-Anne Pearson
May 12, 2020·ChemMedChem·André L C S NascimentoMarlus Chorilli
Sep 2, 2021·AIDS Research and Human Retroviruses·Ana Arancón PardoAlicia Herrero Ambrosio

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