Single Ultra-High-Dose Cholecalciferol to Prevent Vitamin D Deficiency in Pediatric Hematopoietic Stem Cell Transplantation

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Gregory WallaceJonathan Howell

Abstract

Vitamin D deficiency is prevalent among childhood hematopoietic stem cell transplantation (HSCT) recipients and associated with inferior survival at 100 days after transplantation. Achieving and maintaining therapeutic vitamin D levels in HSCT recipients is extremely challenging in the first 3 to 6 months after transplantation due to poor compliance in the setting of mucositis and the concomitant use of critical transplantation drugs that interfere with vitamin D absorption. We sought to evaluate the safety and efficacy of a single, ultra-high-dose of vitamin D given before childhood HSCT to maintain levels in a therapeutic range during the peritransplantation period. Ten HSCT recipients with pretransplantation 25-OH vitamin D (25OHD) level <50 ng/mL and with no history of hypercalcemia, nephrolithiasis, or pathological fractures were enrolled on this pilot study. A single enteral vitamin D dose (maximum 600,000 IU) was administered to each patient based on weight and pretransplantation vitamin D level before the day of HSCT. Vitamin D levels between 30 and 150 ng/mL were considered therapeutic. All patients received close clinical observation and monitoring of 25OHD levels, calcium, phosphate, parathyroid hormone, urine calciu...Continue Reading

Associated Clinical Trials

Citations

Jun 26, 2020·Frontiers in Immunology·Jose Ros SotoJohn A Snowden
Apr 27, 2020·Bone Marrow Transplantation·Sanghee HongNavneet S Majhail
Oct 28, 2019·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Rusha BhandariEtan Orgel
Apr 21, 2021·Bone Marrow Transplantation·Jessica BodeaAlexander Ngwube
Sep 3, 2021·Transplantation and Cellular Therapy·Sarah SwaugerJonathan C Howell
Aug 5, 2021·Anti-cancer Drugs·Ebru YilmazTurkan Patiroglu

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