Single Versus Standard Multiview Assessment of Global Longitudinal Strain for the Diagnosis of Cardiotoxicity During Cancer Therapy

JACC. Cardiovascular Imaging
Paaladinesh ThavendiranathanSUCCOUR Investigators

Abstract

The goal of this study was to compare echocardiographic measurements of global longitudinal strain (GLS) (using 3 apical views) with single-view longitudinal strain (LS, 4- or 2-chamber [4CV_LS and 2CV_LS, respectively]) for detection of cancer-therapy related cardiotoxicity. GLS is useful for the detection of cardiotoxicity, but the need for repeated measurements poses a significant burden on busy echocardiography laboratories. A single-view LS measurement, possibly at point of care, could improve efficiency. Seventeen international centers prospectively recruited 108 patients (mean age 54 ± 13 years) at high risk for cardiotoxicity as part of the ongoing SUCCOUR (Strain Surveillance for Improving Cardiovascular Outcomes During Chemotherapy) randomized controlled trial. Echocardiography performed at baseline and follow-up were analyzed in a core laboratory setting blinded to clinical information. Peak systolic GLS and LS were measured from raw data. Cardiotoxicity was defined by reduction in left ventricular ejection fraction >0.10 to <0.55 or a relative drop in GLS by ≥12%. Cardiotoxicity developed in 46 patients by either criteria. Baseline and follow-up 2-dimensional left ventricular ejection fraction were 61 ± 4% and 58 ± ...Continue Reading

Citations

Oct 10, 2019·European Heart Journal Cardiovascular Imaging·Jutta Bergler-Klein
Jan 5, 2021·European Heart Journal Cardiovascular Imaging·Maria Klara Frey, Jutta Bergler-Klein
Nov 23, 2020·JACC. Cardiovascular Imaging·Kuan-Chih HuangJuey-Jen Hwang
Jan 18, 2020·Journal of the American College of Cardiology·Y Chandrashekhar
Jan 18, 2021·The International Journal of Cardiovascular Imaging·Fei Fei GongNausheen Akhter
Feb 17, 2021·International Journal of Cardiology·L LegrandF Pousset
Mar 13, 2021·The International Journal of Cardiovascular Imaging·Umael KhanGottfried Greve
Jul 16, 2021·International Journal of Radiation Biology·Tianhui Wei, Yufeng Cheng

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