Singlet Oxygen Generation with Chemical Excitation of an Erythrosine-Luminol Conjugate

ACS Omega
Nisa YesilgulEngin U Akkaya

Abstract

Chemical generation of singlet oxygen under biologically relevant conditions is very important, considering the role played by singlet oxygen in cancer therapeutics. We now demonstrate that a luminol derivative can be chemically excited and transfer the excitation energy to the covalently attached photosensitizer derived from erythrosin. A photosensitizer module, when excited in this manner, can generate singlet oxygen in solution. As hydrogen peroxide is present in a relatively high concentration in cancer cells, singlet oxygen generation through chemical excitation may evolve into an important therapeutic approach.

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Citations

Feb 6, 2019·Chemistry : a European Journal·Angelo GiussaniDaniel Roca-Sanjuán
Jul 13, 2019·Chemical Communications : Chem Comm·Chun-Han Wang, Evgueni E Nesterov
Jan 25, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jun Yeon HwangGil Tae Hwang
Nov 28, 2020·Physical Chemistry Chemical Physics : PCCP·Ana Borrego-SánchezDaniel Roca-Sanjuán

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Methods Mentioned

BETA
silica gel column chromatography
column chromatography

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