Singlet oxygen mediates the activation of JNK by UVA radiation in human skin fibroblasts

FEBS Letters
L O KlotzH Sies

Abstract

Ultraviolet A (UVA: 320-400 nm) radiation activates c-Jun-N-terminal kinase (JNK 2) in human skin fibroblasts. Exposure of cells to UVA (300 kJ/m2) led to a 5-fold induction of JNK-activity which was significantly increased in the presence of D2O, an enhancer of the lifetime of singlet oxygen. Sodium azide, a quencher of singlet oxygen, abolished the activation of JNK. A hydroxyl radical scavenger, mannitol, had no effect. Furthermore, photochemically produced singlet oxygen (Rose Bengal plus white light) was found to induce JNK activity. This was enhanced by D2O and inhibited by azide. Thus, singlet oxygen activates and mediates the UVA-induced activation of JNK.

References

May 1, 1991·Molecular and Cellular Biology·Y DevaryM Karin
Feb 1, 1995·The Journal of Investigative Dermatology·M WlaschekK Scharffetter-Kochanek
May 12, 1994·Nature·J M KyriakisJ R Woodgett
Oct 4, 1993·FEBS Letters·K Scharffetter-KochanekH Sies
Sep 1, 1995·Journal of Photochemistry and Photobiology. B, Biology·K Müller-BreitkreutzH Sies
Apr 8, 1996·FEBS Letters·M Djavaheri-MergnyJ C Mazière
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·K G MendelsonK E Paulson
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·S Grether-BeckJ Krutmann

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Citations

Feb 22, 2001·Biochemical and Biophysical Research Communications·C MazièreJ C Mazière
Jun 20, 2006·The Journal of Membrane Biology·C LaT F McDonald
Jan 7, 2004·Journal of Photochemistry and Photobiology. B, Biology·Zhimin TongAndrew J Rainbow
Mar 17, 2004·Seminars in Cancer Biology·Michael A Bachelor, G Tim Bowden
Jun 26, 1998·Free Radical Biology & Medicine·S W Ryter, R M Tyrrell
Feb 22, 2002·European Journal of Biochemistry·Yukihito KabuyamaYoshimi Homma
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·K M Hanson, J D Simon
Aug 20, 2009·The Journal of Biological Chemistry·Betul CatalgolTilman Grune
May 30, 2002·Biological Chemistry·Lars-Oliver Klotz
Feb 24, 2004·Biological Chemistry·Maria C RamosPeter Brenneisen
Jun 6, 2003·The Journal of Investigative Dermatology·Swarna Ekanayake MudiyanselageJens J Thiele
Jul 18, 2015·Redox Biology·Lars-Oliver KlotzMaria Monsalve
Apr 5, 2013·Journal of Cellular and Molecular Medicine·Sung H LimHyong J Lee
Aug 14, 2003·Biochemical and Biophysical Research Communications·Holger SteinbrennerPeter Brenneisen
Feb 7, 2006·Free Radical Biology & Medicine·Antonio Valencia, Irene E Kochevar
Apr 23, 2005·Biochemical and Biophysical Research Communications·Yuki NagaokaJunichi Fujii
Oct 22, 2013·Nitric Oxide : Biology and Chemistry·Christian OpländerChristoph V Suschek
Jul 25, 2015·Zeitschrift für Gerontologie und Geriatrie·Andreas Simm, Lars-Oliver Klotz
Mar 1, 2011·Free Radical Biology & Medicine·Ruben E A MussonNico P M Smit
Jan 24, 2012·Mutation Research. Reviews in Mutation Research·Lucymara F Agnez-LimaCarlos F M Menck
Apr 18, 2009·Molecular Aspects of Medicine·Tobias JungTilman Grune
Dec 29, 2004·Free Radical Research·Ronit LaviRachel Lubart
Sep 30, 2004·Free Radical Research·Stefan M SchiekeLars-Oliver Klotz
Jan 30, 2003·Science's STKE : Signal Transduction Knowledge Environment·Ann M Bode, Zigang Dong
Mar 22, 2000·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·T W Stief, J Fareed
Mar 3, 2004·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·André MahnsHelmut Sies
Mar 29, 2001·Photochemistry and Photobiology·Y KabuyamaY Homma
Apr 20, 2004·Journal of Cellular Biochemistry·Wen-Hsiung Chan, Hsin-Jung Wu
Jun 7, 2007·Journal of Cellular Biochemistry·Himanshi Narang, Malini Krishna

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