Singlet oxygen-responsive micelles for enhanced photodynamic therapy

Journal of Controlled Release : Official Journal of the Controlled Release Society
Xiaodan LiYanjun Zhao

Abstract

Photodynamic therapy (PDT) efficacy is limited by the very short half-life and limited diffusion radius of singlet oxygen (1O2). We report a 1O2-responsive micellar nanoplatform subject to considerable size-expansion upon light triggering to facilitate on-demand release of photosensitizers. Imidazole, a well-known 1O2 scavenger, was incorporated in the hydrophobic core of amphiphilic copolymer micelles, and was used to coordinate with biocompatible Zn2+ and encapsulate the photosensitizer chlorin e6 (Ce6). The micelles are highly sensitive to light irradiation: 1O2 triggering induced dramatic particle size expansion due to the conversion of imidazole to hydrophilic urea, resulting in instantaneous release of Ce6 and rapid intracellular distribution. This 1O2-responsive, size-expandable nanosystem delivered substantially more Ce6 to tumor sites as compared to free Ce6, and exhibited improved anti-tumor efficacy in vivo in 4T1 tumor-bearing mice. This work opens new avenues of particle expansion-induced PDT enhancement by controlled imidazole chemistry.

Citations

Mar 24, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Susan Callaghan, Mathias O Senge
Dec 9, 2017·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Angelo LanzilottoCornelia G Palivan
Mar 21, 2019·Drug Development Research·Mine Silindir-GunayAsuman Yekta Ozer
Oct 9, 2019·Pharmaceuticals·Sara Sansaloni-PastorNorbert Lange
Sep 8, 2020·Advanced Healthcare Materials·Dandan LiJun Wu
Jan 28, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yi-Hong GongJie Liu
Apr 7, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Guangqin LiuYanjun Zhao
Jul 10, 2020·Journal of Biomaterials Science. Polymer Edition·Bo LiYanhai Li
Feb 14, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Abid Hussain, Shengrong Guo
Feb 23, 2020·Beilstein Journal of Nanotechnology·Maxime DemazeauBarbara Lonetti
Dec 29, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Camila G DarivaArménio C Serra
Feb 24, 2021·Artificial Cells, Nanomedicine, and Biotechnology·Shudi YangTongtong Yu
Feb 21, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Balaram Ghosh, Swati Biswas
Sep 25, 2020·Colloids and Surfaces. B, Biointerfaces·Camila G DarivaArménio C Serra
Jun 14, 2018·ACS Applied Materials & Interfaces·Ran TaoYanjun Zhao
Nov 18, 2017·Biomacromolecules·Min GaoGuohui Li
Oct 31, 2020·Chemical Reviews·Roy WeinstainPetr Klán
Jun 15, 2019·ACS Applied Materials & Interfaces·Qi YanYanjun Zhao
Nov 16, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Oanh-Vu Pham-NguyenHyuk Sang Yoo
Dec 4, 2021·ChemMedChem·Ezel Öztürk GündüzElif Okutan

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